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Clinical Factors and Disease Course Related to Diagnostic Delay in Korean Crohn's Disease Patients: Results from the CONNECT Study

Diagnostic delay frequently occurs in Crohn's disease (CD) patients because of diagnostic limitations. However, diagnostic delay and its related factors remain poorly defined. Therefore, we aimed to identify the predictors associated with diagnostic delay and to evaluate the impact of diagnosti...

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Published in:PloS one 2015-12, Vol.10 (12), p.e0144390-e0144390
Main Authors: Moon, Chang Mo, Jung, Sung-Ae, Kim, Seong-Eun, Song, Hyun Joo, Jung, Yunho, Ye, Byong Duk, Cheon, Jae Hee, Kim, You Sun, Kim, Young-Ho, Kim, Joo Sung, Han, Dong Soo
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cited_by cdi_FETCH-LOGICAL-c692t-a15f5bf07bb0a1cec4b71eefd8f2aba204bebff81596bcdf5956bad8cc79828b3
cites cdi_FETCH-LOGICAL-c692t-a15f5bf07bb0a1cec4b71eefd8f2aba204bebff81596bcdf5956bad8cc79828b3
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creator Moon, Chang Mo
Jung, Sung-Ae
Kim, Seong-Eun
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Kim, You Sun
Kim, Young-Ho
Kim, Joo Sung
Han, Dong Soo
description Diagnostic delay frequently occurs in Crohn's disease (CD) patients because of diagnostic limitations. However, diagnostic delay and its related factors remain poorly defined. Therefore, we aimed to identify the predictors associated with diagnostic delay and to evaluate the impact of diagnostic delay on clinical course in a Korean CD patient cohort. We performed a multicenter retrospective analysis of 1,047 CD patients registered in the Crohn's Disease Clinical Network and Cohort study in Korea. The mean interval of diagnostic delay was 16.0 ± 33.1 months. Multivariate analysis showed that older age at diagnosis (≥40 years) (p = 0.014), concomitant upper gastrointestinal (UGI) disease (p = 0.012) and penetrating disease behavior at diagnosis (p = 0.001) were positively associated with long diagnostic delay (≥18 months). During the longitudinal follow-up, long diagnostic delay was independently predictive of further development of intestinal stenosis (hazard ratio [HR], 1.43; 95% confidence interval [CI], 1.07-1.93; p = 0.017), internal fistulas (HR, 1.62; 95% CI, 1.12-2.33; p = 0.011), and perianal fistulas (HR, 1.38; 95% CI, 1.06-1.80; p = 0.016). However, as for the risk of abscess formation, bowel perforation, and CD-related abdominal surgery, no significant association with diagnostic delay was observed. Older age at diagnosis, UGI involvement, and penetrating behavior are associated with long diagnostic delay in Korean CD patients. Moreover, diagnostic delay is associated with an increased risk of CD-related complications such as intestinal stenosis, internal fistulas, and perianal fistulas.
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However, diagnostic delay and its related factors remain poorly defined. Therefore, we aimed to identify the predictors associated with diagnostic delay and to evaluate the impact of diagnostic delay on clinical course in a Korean CD patient cohort. We performed a multicenter retrospective analysis of 1,047 CD patients registered in the Crohn's Disease Clinical Network and Cohort study in Korea. The mean interval of diagnostic delay was 16.0 ± 33.1 months. Multivariate analysis showed that older age at diagnosis (≥40 years) (p = 0.014), concomitant upper gastrointestinal (UGI) disease (p = 0.012) and penetrating disease behavior at diagnosis (p = 0.001) were positively associated with long diagnostic delay (≥18 months). During the longitudinal follow-up, long diagnostic delay was independently predictive of further development of intestinal stenosis (hazard ratio [HR], 1.43; 95% confidence interval [CI], 1.07-1.93; p = 0.017), internal fistulas (HR, 1.62; 95% CI, 1.12-2.33; p = 0.011), and perianal fistulas (HR, 1.38; 95% CI, 1.06-1.80; p = 0.016). However, as for the risk of abscess formation, bowel perforation, and CD-related abdominal surgery, no significant association with diagnostic delay was observed. Older age at diagnosis, UGI involvement, and penetrating behavior are associated with long diagnostic delay in Korean CD patients. Moreover, diagnostic delay is associated with an increased risk of CD-related complications such as intestinal stenosis, internal fistulas, and perianal fistulas.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26647084</pmid><doi>10.1371/journal.pone.0144390</doi><oa>free_for_read</oa></addata></record>
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1932-6203
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subjects Abdomen
Abdominal surgery
Adolescent
Adult
Aged
Aged, 80 and over
Care and treatment
Child
Clinical outcomes
Complications
Complications and side effects
Confidence intervals
Crohn Disease - diagnosis
Crohn Disease - pathology
Crohn's disease
Crohns disease
Delay
Diagnosis
Diagnostic systems
Disease control
Endoscopy
Female
Fistula
Helicobacter pylori
Hospitals
Humans
Immunologic factors
Inflammation
Inflammatory bowel disease
Influence
Internal medicine
Intestine
Irritable bowel syndrome
Male
Medical diagnosis
Medical records
Medicine
Middle Aged
Multivariate analysis
Patients
Perforation
Republic of Korea
Risk factors
Stenosis
Studies
Surgery
Systematic review
Young Adult
title Clinical Factors and Disease Course Related to Diagnostic Delay in Korean Crohn's Disease Patients: Results from the CONNECT Study
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