Differences in Visual-Spatial Input May Underlie Different Compression Properties of Firing Fields for Grid Cell Modules in Medial Entorhinal Cortex

Firing fields of grid cells in medial entorhinal cortex show compression or expansion after manipulations of the location of environmental barriers. This compression or expansion could be selective for individual grid cell modules with particular properties of spatial scaling. We present a model for...

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Bibliographic Details
Published in:PLoS computational biology 2015-11, Vol.11 (11), p.e1004596-e1004596
Main Authors: Raudies, Florian, Hasselmo, Michael E
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Agricultural banking
Animals
Bias
Charged particles
Computational Biology
Entorhinal cortex
Entorhinal Cortex - cytology
Entorhinal Cortex - physiology
Experiments
Gene mutations
Hippocampus - physiology
Models, Neurological
Noise
Rats
Spatial Navigation - physiology
Visual Cortex - physiology
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Summary:Firing fields of grid cells in medial entorhinal cortex show compression or expansion after manipulations of the location of environmental barriers. This compression or expansion could be selective for individual grid cell modules with particular properties of spatial scaling. We present a model for differences in the response of modules to barrier location that arise from different mechanisms for the influence of visual features on the computation of location that drives grid cell firing patterns. These differences could arise from differences in the position of visual features within the visual field. When location was computed from the movement of visual features on the ground plane (optic flow) in the ventral visual field, this resulted in grid cell spatial firing that was not sensitive to barrier location in modules modeled with small spacing between grid cell firing fields. In contrast, when location was computed from static visual features on walls of barriers, i.e. in the more dorsal visual field, this resulted in grid cell spatial firing that compressed or expanded based on the barrier locations in modules modeled with large spacing between grid cell firing fields. This indicates that different grid cell modules might have differential properties for computing location based on visual cues, or the spatial radius of sensitivity to visual cues might differ between modules.
ISSN:1553-7358
1553-734X
1553-7358
DOI:10.1371/journal.pcbi.1004596