HIV-Helicobacter pylori Co-Infection: Antibiotic Resistance, Prevalence, and Risk Factors

• Published in: PloS one 2015-12, Vol.10 (12), p.e0145119-e0145119
• Main Authors: Nkuize, Marcel, De Wit, Stéphane, Muls, Vinciane, Delforge, Marc, Miendje Deyi, Véronique Y, Cadière, Guy B, Buset, Michel
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Acquired Immunodeficiency Syndrome - blood; Acquired Immunodeficiency Syndrome - complications; Acquired Immunodeficiency Syndrome - epidemiology; Adult; Aged; AIDS; Antibiotic resistance; Antibiotics; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Belgium - epidemiology; Biopsy; Body mass; Body mass index; Body size; CD4 antigen; Clostridium difficile; Coinfection - epidemiology; Complications and side effects; Disease resistance; Drug resistance; Drug therapy; Endoscopy; Female; Gastroenterology; Gastrointestinal surgery; Health aspects; Health risks; Helicobacter Infections - blood; Helicobacter Infections - complications; Helicobacter Infections - epidemiology; Helicobacter pylori; Hepatology; Histopathology; HIV; HIV infections; HIV-1; Hospitals; Human immunodeficiency virus; Humans; Infections; Infectious diseases; Levofloxacin; Male; Metronidazole; Microbial drug resistance; Middle Aged; Minority & ethnic groups; Patients; Physiological aspects; Pneumonia; Population; Prevalence; Prevalence studies (Epidemiology); Prospective Studies; Resistance factors; Risk analysis; Risk Factors; Sex; Sexually transmitted diseases; STD; Strains (organisms); Substance abuse treatment; Toxoplasma gondii; Viruses; Zeidae
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0145119

Patients infected with human immunodeficiency virus (HIV) are living longer due to the availability of more potent treatments. However, prescription of antibiotics to treat or prevent infections in these patients may increase the likelihood of co-infection with antibiotic-resistant species. To compare antimicrobial susceptibility of Helicobacter pylori (H. pylori) in HIV-positive and HIV-negative patients and assess risk-factors for resistance. We prospectively collected data from consecutive HIV-positive and HIV-negative patients undergoing upper gastrointestinal endoscopy. Patients with H. pylori-positive gastric biopsies who had never received H. pylori treatment were included. Of the 353 patients included, 93 were HIV-positive and 260 HIV-negative. Among the HIV-positive patients, 56 (60%) had been infected for