The Defect in Autophagy Induction by Clinical Isolates of Mycobacterium Tuberculosis Is Correlated with Poor Tuberculosis Outcomes

Tuberculosis (TB) represents a major global health problem. The prognosis of clinically active tuberculosis depends on the complex interactions between Mycobacterium tuberculosis (Mtb) and its host. In recent years, autophagy receives particular attention for its role in host defense against intrace...

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Bibliographic Details
Published in:PloS one 2016-01, Vol.11 (1), p.e0147810-e0147810
Main Authors: Li, Furong, Gao, Bo, Xu, Wei, Chen, Ling, Xiong, Sidong
Format: Article
Language:English
Subjects:
Adult
Animals
Antibiotics
Antitubercular Agents
Autophagy
Autophagy (Cytology)
Biology and Life Sciences
Cell death
Cell Line
Clinical isolates
Demographics
Drug resistance
Erythrocyte sedimentation rate
Erythrocytes
Female
Genetic aspects
Genetic diversity
Global health
Health risks
Hemoglobin
Host-Pathogen Interactions
Humans
Immunology
Infections
Laboratories
Laboratory tests
Leukocytes
Macrophages
Macrophages - microbiology
Macrophages - pathology
Male
Medicine and Health Sciences
Mice
Middle Aged
Mycobacterium tuberculosis
Mycobacterium tuberculosis - isolation & purification
Mycobacterium tuberculosis - physiology
Pathogenesis
Patient outcomes
Patients
Phagocytosis
Physical Sciences
Physiological aspects
Prognosis
Regression analysis
Research and Analysis Methods
Respiratory diseases
Risk factors
Studies
Tobacco
Treatment Outcome
Tuberculosis
Tuberculosis - diagnosis
Tuberculosis - epidemiology
Tuberculosis - physiopathology
Tuberculosis - therapy
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Summary:Tuberculosis (TB) represents a major global health problem. The prognosis of clinically active tuberculosis depends on the complex interactions between Mycobacterium tuberculosis (Mtb) and its host. In recent years, autophagy receives particular attention for its role in host defense against intracellular pathogens, including Mtb. In present study, we aim to investigate the relationship of autophagy induction by clinical isolates of Mtb with the clinical outcomes in patients with TB. We collected 185 clinical isolates of Mtb, and determined the effect of these Mtb isolates on autophagy induction in macrophages. It was found that most of clinical isolates of Mtb were able to induce autophagosome formation in macrophages, however, the autophagy-inducing ability varied significantly among different isolates. Of importance, our results revealed that patients infected by Mtb with poor autophagy-inducing ability displayed more severe radiographic extent of disease (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0147810