Absence of Tumor-Infiltrating Lymphocyte Is a Reproducible Predictive Factor for Sentinel Lymph Node Metastasis: A Multicenter Database Study by the Brazilian Melanoma Group

The aim of this study is to confirm the function of tumor-infiltrating lymphocytes (TILs) in sentinel lymph node (SLN) metastasis. This retrospective study included 633 patients with invasive melanoma who underwent sentinel lymph node biopsy in 7 referral centers certified by the Brazilian Melanoma...

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Published in:PloS one 2016-02, Vol.11 (2), p.e0148160-e0148160
Main Authors: Duprat, João Pedreira, Brechtbülh, Eduard René, Costa de Sá, Bianca, Enokihara, Mauro, Fregnani, Jose Humberto, Landman, Gilles, Maia, Marcus, Riccardi, Felice, Belfort, Francisco Alberto, Wainstein, Alberto, Moredo, Luciana F, Steck, Higino, Brandão, Miguel, Moreno, Marcelo, Miranda, Eduardo, Santos, Ivan Dunshee de Oliveira
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Biopsy
Brazil
Cancer
Cancer metastasis
Cell Count
Confidence intervals
Databases, Factual
Female
Hospitals
Humans
Immunotherapy
Lymph
Lymph nodes
Lymphatic Metastasis
Lymphatic system
Lymphocytes
Lymphocytes, Tumor-Infiltrating - cytology
Male
Medical prognosis
Medical records
Medical schools
Medicine and Health Sciences
Melanoma
Melanoma - diagnosis
Melanoma - immunology
Melanoma - pathology
Metastases
Metastasis
Middle Aged
Mitosis
Patients
Prognosis
Quality of life
Retrospective Studies
Risk analysis
Risk factors
Studies
Tumor-infiltrating lymphocytes
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cited_by cdi_FETCH-LOGICAL-c692t-3e196f5ef2b3ef2f808a12ced32f3af131997f15a2276d59aac6f7507c036b093
cites cdi_FETCH-LOGICAL-c692t-3e196f5ef2b3ef2f808a12ced32f3af131997f15a2276d59aac6f7507c036b093
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container_title PloS one
container_volume 11
creator Duprat, João Pedreira
Brechtbülh, Eduard René
Costa de Sá, Bianca
Enokihara, Mauro
Fregnani, Jose Humberto
Landman, Gilles
Maia, Marcus
Riccardi, Felice
Belfort, Francisco Alberto
Wainstein, Alberto
Moredo, Luciana F
Steck, Higino
Brandão, Miguel
Moreno, Marcelo
Miranda, Eduardo
Santos, Ivan Dunshee de Oliveira
description The aim of this study is to confirm the function of tumor-infiltrating lymphocytes (TILs) in sentinel lymph node (SLN) metastasis. This retrospective study included 633 patients with invasive melanoma who underwent sentinel lymph node biopsy in 7 referral centers certified by the Brazilian Melanoma Group. Independent risk factors of sentinel node metastasis (SNL) were identified by multiple logistic regression. SLN metastasis was detected in 101 of 633 cases (16.1%) and in 93 of 428 patients (21.7%) when melanomas ≤ 1mm were excluded. By multiple logistic regression, the absence of TILs was as an independent risk factor of SLN metastasis (OR = 1.8; 95%CI: 1.1-3.0), in addition to Breslow index (greater than 2.00 mm), lymph vascular invasion, and presence of mitosis. SLNB can identify patients who might benefit from immunotherapy, and the determination of predictors of SLNB positivity can help select the proper population for this type of therapy. The absence of TILs is a reproducible parameter that can predict SLNB positivity in melanoma patients, since this study was made with several centers with different dermatopathologists.
doi_str_mv 10.1371/journal.pone.0148160
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Marcus</au><au>Riccardi, Felice</au><au>Belfort, Francisco Alberto</au><au>Wainstein, Alberto</au><au>Moredo, Luciana F</au><au>Steck, Higino</au><au>Brandão, Miguel</au><au>Moreno, Marcelo</au><au>Miranda, Eduardo</au><au>Santos, Ivan Dunshee de Oliveira</au><au>Slominski, Andrzej T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absence of Tumor-Infiltrating Lymphocyte Is a Reproducible Predictive Factor for Sentinel Lymph Node Metastasis: A Multicenter Database Study by the Brazilian Melanoma Group</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-02-09</date><risdate>2016</risdate><volume>11</volume><issue>2</issue><spage>e0148160</spage><epage>e0148160</epage><pages>e0148160-e0148160</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The aim of this study is to confirm the function of tumor-infiltrating lymphocytes (TILs) in sentinel lymph node (SLN) metastasis. This retrospective study included 633 patients with invasive melanoma who underwent sentinel lymph node biopsy in 7 referral centers certified by the Brazilian Melanoma Group. Independent risk factors of sentinel node metastasis (SNL) were identified by multiple logistic regression. SLN metastasis was detected in 101 of 633 cases (16.1%) and in 93 of 428 patients (21.7%) when melanomas ≤ 1mm were excluded. By multiple logistic regression, the absence of TILs was as an independent risk factor of SLN metastasis (OR = 1.8; 95%CI: 1.1-3.0), in addition to Breslow index (greater than 2.00 mm), lymph vascular invasion, and presence of mitosis. SLNB can identify patients who might benefit from immunotherapy, and the determination of predictors of SLNB positivity can help select the proper population for this type of therapy. The absence of TILs is a reproducible parameter that can predict SLNB positivity in melanoma patients, since this study was made with several centers with different dermatopathologists.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26859408</pmid><doi>10.1371/journal.pone.0148160</doi><oa>free_for_read</oa></addata></record>
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subjects Biology and Life Sciences
Biopsy
Brazil
Cancer
Cancer metastasis
Cell Count
Confidence intervals
Databases, Factual
Female
Hospitals
Humans
Immunotherapy
Lymph
Lymph nodes
Lymphatic Metastasis
Lymphatic system
Lymphocytes
Lymphocytes, Tumor-Infiltrating - cytology
Male
Medical prognosis
Medical records
Medical schools
Medicine and Health Sciences
Melanoma
Melanoma - diagnosis
Melanoma - immunology
Melanoma - pathology
Metastases
Metastasis
Middle Aged
Mitosis
Patients
Prognosis
Quality of life
Retrospective Studies
Risk analysis
Risk factors
Studies
Tumor-infiltrating lymphocytes
title Absence of Tumor-Infiltrating Lymphocyte Is a Reproducible Predictive Factor for Sentinel Lymph Node Metastasis: A Multicenter Database Study by the Brazilian Melanoma Group
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