Dual Energy Spectral CT Imaging for Colorectal Cancer Grading: A Preliminary Study

To assess the diagnostic value of dual energy spectral CT imaging for colorectal cancer grading using the quantitative iodine density measurements in both arterial phase (AP) and venous phase (VP). 81 colorectal cancer patients were divided into two groups based on their pathological findings: a low...

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Bibliographic Details
Published in:PloS one 2016-02, Vol.11 (2), p.e0147756-e0147756
Main Authors: Gong, Hong-Xia, Zhang, Ke-Bei, Wu, Lian-Ming, Baigorri, Brian F, Yin, Yan, Geng, Xiao-Chuan, Xu, Jian-Rong, Zhu, Jiong
Format: Article
Language:English
Subjects:
Abdomen
Aged
Angiogenesis
Biology and Life Sciences
Cancer
Care and treatment
CAT scans
Classification
Colon - diagnostic imaging
Colon - pathology
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnostic imaging
Colorectal Neoplasms - pathology
Complications and side effects
Computed tomography
Density
Development and progression
Diagnosis
Diagnostic systems
Evaluation
Feasibility Studies
Female
Grading
Hospitals
Humans
Iodine
Lesions
Male
Medical diagnosis
Medical imaging
Medical prognosis
Medical screening
Medicine
Medicine and Health Sciences
Metastasis
Middle Aged
Neoplasm Grading
NMR
Nuclear magnetic resonance
Patient outcomes
Patients
Physical Sciences
Psoas muscle
Quality
Research and Analysis Methods
Retrospective Studies
Tomography, X-Ray Computed
Tumors
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Summary:To assess the diagnostic value of dual energy spectral CT imaging for colorectal cancer grading using the quantitative iodine density measurements in both arterial phase (AP) and venous phase (VP). 81 colorectal cancer patients were divided into two groups based on their pathological findings: a low grade group including well (n = 13) and moderately differentiated cancer (n = 24), and a high grade group including poorly differentiated (n = 42) and signet ring cell cancer (n = 2). Iodine density (ID) in the lesions was derived from the iodine-based material decomposition (MD) image and normalized to that in the psoas muscle to obtain normalized iodine density (NID). The difference in ID and NID between AP and VP was calculated. The ID and NID values of the low grade cancer group were, 14.65 ± 3.38 mg/mL and 1.70 ± 0.33 in AP, and 21.90 ± 3.11 mg/mL and 2.05 ± 0.32 in VP, respectively. The ID and NID values for the high grade cancer group were 20.63 ± 3.72 mg/mL and 2.95 ± 0.72 in AP, and 26.27 ± 3.10mg/mL and 3.51 ± 1.12 in VP, respectively. There was significant difference for ID and NID between the low grade and high grade cancer groups in both AP and VP (all p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0147756