Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster

Organismal size depends on the interplay between genetic and environmental factors. Genome-wide association (GWA) analyses in humans have implied many genes in the control of height but suffer from the inability to control the environment. Genetic analyses in Drosophila have identified conserved sig...

Full description

Saved in:
Bibliographic Details
Published in:PLoS genetics 2016-01, Vol.12 (1), p.e1005616-e1005616
Main Authors: Vonesch, Sibylle Chantal, Lamparter, David, Mackay, Trudy F C, Bergmann, Sven, Hafen, Ernst
Format: Article
Language:English
Subjects:
Animals
Body Size - genetics
Candidates
Drosophila
Drosophila melanogaster - genetics
Drosophila melanogaster - growth & development
Experiments
Genes
Genetic aspects
Genetic Variation
Genome-wide association studies
Genome-Wide Association Study
Genomes
Growth
Humans
Insects
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait Loci - genetics
Signal Transduction
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Organismal size depends on the interplay between genetic and environmental factors. Genome-wide association (GWA) analyses in humans have implied many genes in the control of height but suffer from the inability to control the environment. Genetic analyses in Drosophila have identified conserved signaling pathways controlling size; however, how these pathways control phenotypic diversity is unclear. We performed GWA of size traits using the Drosophila Genetic Reference Panel of inbred, sequenced lines. We find that the top associated variants differ between traits and sexes; do not map to canonical growth pathway genes, but can be linked to these by epistasis analysis; and are enriched for genes and putative enhancers. Performing GWA on well-studied developmental traits under controlled conditions expands our understanding of developmental processes underlying phenotypic diversity.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1005616