The Pattern of Adipose Tissue Accumulation during Early Infancy Provides an Environment for the Development of Dengue Hemorrhagic Fever

Dengue is the most prevalent arthropod-borne viral illness in humans with half of the world's population at risk. During early infancy, severe dengue can develop after a primary dengue virus infection. There has been a clinical observation that severe dengue during the first year of life is see...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2015-12, Vol.9 (12), p.e0004267-e0004267
Main Authors: Libraty, Daniel H, Wang, Pengyan, Guo, Zhiru, Bigcas, Venelle, Brion, Job D, Capeding, Rosario Z
Format: Article
Language:English
Subjects:
Adipocytes
Adipocytes - virology
Adipose Tissue - physiology
Adipose Tissue - virology
Adipose tissues
Children
Cytokines
Dengue
Dengue fever
Dengue virus
Dengue Virus - growth & development
Disease Susceptibility
Diseases
Experiments
Health aspects
Humans
Illnesses
Immune response
Infant
Infections
Macrophages - virology
Observations
Prospective Studies
Risk factors
Rodents
Severe Dengue - epidemiology
Severe Dengue - pathology
Tumor necrosis factor-TNF
Viruses
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Summary:Dengue is the most prevalent arthropod-borne viral illness in humans with half of the world's population at risk. During early infancy, severe dengue can develop after a primary dengue virus infection. There has been a clinical observation that severe dengue during the first year of life is seen only in chubby infants. We examined the associations between the development of severe dengue and adipose tissue accumulation patterns during the first year of life in a prospective observational clinical study of infants and dengue virus infections. We found that adipose tissue contains two potential targets for dengue virus infection and production- adipocytes and adipose tissue macrophages. During the first year of life, total body adiposity and visceral adipose tissue stores were at their highest levels in early infancy. Early infancy was also characterized by a relative decrease in alternatively activated (anti-inflammatory) macrophages, and a relative increase in circulating pro-inflammatory cytokines. The data has been used to propose a model where the adipose tissue accumulation pattern and pro-inflammatory environment during early infancy provide the conditions for the potential development of severe dengue in immune-susceptible infants.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0004267