Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity

Studies suggest that fish consumption can restrict weight gain. However, little is known about how fish consumption affects gestational weight gain (GWG), and whether this relationship depends on genetic makeup. To examine the association between fish consumption and GWG, and whether this relationsh...

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Bibliographic Details
Published in:PloS one 2016-03, Vol.11 (3), p.e0150105-e0150105
Main Authors: Larsen, Sofus C, Ängquist, Lars, Laurin, Charles, Morgen, Camilla S, Jakobsen, Marianne U, Paternoster, Lavinia, Smith, George Davey, Olsen, Sjurdur F, Sørensen, Thorkild I A, Nohr, Ellen A
Format: Article
Language:English
Subjects:
Adult
Alcohol use
Analysis
Biology and Life Sciences
Body mass
Body Mass Index
Body size
Body weight gain
Case-Control Studies
Children
Cohort Studies
Consumption
Correlation analysis
Diet
Epidemiology
Exercise
Fatty acids
Female
Fish
Fish (Food product)
Food
Genetic Predisposition to Disease
Genotype
Health aspects
Health care
Hospitals
Humans
Maternal Nutritional Physiological Phenomena - physiology
Medicine and Health Sciences
Metabolism
Molecular genetics
Nutrition research
Obesity
Obesity - genetics
Obesity - physiopathology
Oils & fats
Parents
Peroxisome proliferator-activated receptors
Pregnancy
Preventive medicine
Proteins
Public health
Risk Factors
Seafood
Single-nucleotide polymorphism
Statistical analysis
Statistical significance
Studies
Validity
Weight control
Weight gain
Weight Gain - physiology
Womens health
Young Adult
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Summary:Studies suggest that fish consumption can restrict weight gain. However, little is known about how fish consumption affects gestational weight gain (GWG), and whether this relationship depends on genetic makeup. To examine the association between fish consumption and GWG, and whether this relationship is dependent on molecular genetic predisposition to obesity. A nested case-cohort study based on the Danish National Birth Cohort (DNBC) sampling the most obese women (n = 990) and a random sample of the remaining participants (n = 1,128). Replication of statistically significant findings was attempted in the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 4,841). We included 32 body mass index (BMI) associated single nucleotide polymorphisms (SNPs) and 5 SNPs found associated with GWG. BMI associated SNPs were combined in a genetic risk score (GRS). Associations between consumption of fish, GRS or individual variants and GWG were analysed, and interactions between fish and the GRS or individual variants were examined. In the DNBC, each portion/week (150 g) of fatty fish was associated with a higher GWG of 0.58 kg (95% CI: 0.16, 0.99, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0150105