Abnormal Fixational Eye Movements in Amblyopia

• Published in: PloS one 2016-03, Vol.11 (3), p.e0149953-e0149953
• Main Authors: Shaikh, Aasef G, Otero-Millan, Jorge, Kumar, Priyanka, Ghasia, Fatema F
• Format: Article
• Language: English
• Subjects: Abnormalities; Amblyopia; Amblyopia - physiopathology; Analysis; Biology and Life Sciences; Blindness; Child; Child, Preschool; Children; Comparative analysis; Consent; Drift; Eye; Eye - physiopathology; Eye Movements; Fixation, Ocular; Guardians; Humans; Laboratories; Medicine and Health Sciences; Motility; Neurology; Pediatric diseases; Physical Sciences; Physiology; Research and Analysis Methods; Review boards; Risk factors; Saccades; Saccades (Eye movements); Saccadic eye movements; Social Sciences; Stability; Stokes, Louis; Strabismus - physiopathology; Velocity; Viewing; Visual Acuity; Visual perception; Visual system
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0149953

Fixational saccades shift the foveal image to counteract visual fading related to neural adaptation. Drifts are slow eye movements between two adjacent fixational saccades. We quantified fixational saccades and asked whether their changes could be attributed to pathologic drifts seen in amblyopia, one of the most common causes of blindness in childhood. Thirty-six pediatric subjects with varying severity of amblyopia and eleven healthy age-matched controls held their gaze on a visual target. Eye movements were measured with high-resolution video-oculography during fellow eye-viewing and amblyopic eye-viewing conditions. Fixational saccades and drifts were analyzed in the amblyopic and fellow eye and compared with controls. We found an increase in the amplitude with decreased frequency of fixational saccades in children with amblyopia. These alterations in fixational eye movements correlated with the severity of their amblyopia. There was also an increase in eye position variance during drifts in amblyopes. There was no correlation between the eye position variance or the eye velocity during ocular drifts and the amplitude of subsequent fixational saccade. Our findings suggest that abnormalities in fixational saccades in amblyopia are independent of the ocular drift. This investigation of amblyopia in pediatric age group quantitatively characterizes the fixation instability. Impaired properties of fixational saccades could be the consequence of abnormal processing and reorganization of the visual system in amblyopia. Paucity in the visual feedback during amblyopic eye-viewing condition can attribute to the increased eye position variance and drift velocity.