Comparative Epidemiology of Human Infections with Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses among Healthcare Personnel

The largest nosocomial outbreak of Middle East respiratory syndrome (MERS) occurred in South Korea in 2015. Health Care Personnel (HCP) are at high risk of acquiring MERS-Coronavirus (MERS-CoV) infections, similar to the severe acute respiratory syndrome (SARS)-Coronavirus (SARS-CoV) infections firs...

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Bibliographic Details
Published in:PloS one 2016-03, Vol.11 (3), p.e0149988-e0149988
Main Authors: Liu, Shelan, Chan, Ta-Chien, Chu, Yu-Tseng, Wu, Joseph Tsung-Shu, Geng, Xingyi, Zhao, Na, Cheng, Wei, Chen, Enfu, King, Chwan-Chuen
Format: Article
Language:English
Subjects:
Adult
Aged
Biology and life sciences
Chiroptera
Coronaviridae
Coronavirus Infections - epidemiology
Coronavirus Infections - mortality
Coronavirus Infections - virology
Coronaviruses
COVID-19
Disease Outbreaks
Epidemics
Epidemiology
Fatalities
Female
Health aspects
Health care
Health Personnel - statistics & numerical data
Health risks
Humans
Laboratories
Male
Medical personnel
Medicine and Health Sciences
Middle Aged
Middle East respiratory syndrome
Middle East Respiratory Syndrome Coronavirus - isolation & purification
Middle East Respiratory Syndrome Coronavirus - physiology
Nosocomial infection
Outbreaks
People and Places
Personnel
Preventive medicine
Respiratory diseases
Risk factors
SARS Virus - isolation & purification
SARS Virus - physiology
Severe acute respiratory syndrome
Severe Acute Respiratory Syndrome - epidemiology
Severe Acute Respiratory Syndrome - mortality
Severe Acute Respiratory Syndrome - virology
Survival Rate
Taiwan - epidemiology
Young Adult
Zoonoses
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Summary:The largest nosocomial outbreak of Middle East respiratory syndrome (MERS) occurred in South Korea in 2015. Health Care Personnel (HCP) are at high risk of acquiring MERS-Coronavirus (MERS-CoV) infections, similar to the severe acute respiratory syndrome (SARS)-Coronavirus (SARS-CoV) infections first identified in 2003. This study described the similarities and differences in epidemiological and clinical characteristics of 183 confirmed global MERS cases and 98 SARS cases in Taiwan associated with HCP. The epidemiological findings showed that the mean age of MERS-HCP and total MERS cases were 40 (24~74) and 49 (2~90) years, respectively, much older than those in SARS [SARS-HCP: 35 (21~68) years, p = 0.006; total SARS: 42 (0~94) years, p = 0.0002]. The case fatality rates (CFR) was much lower in MERS-HCP [7.03% (9/128)] or SARS-HCP [12.24% (12/98)] than the MERS-non-HCP [36.96% (34/92), p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0149988