ESA Hyporesponsiveness Is Associated with Adverse Events in Maintenance Hemodialysis (MHD) Patients, But Not with Iron Storage

It has been reported that hyporesponsiveness to erythropoiesis-stimulating agent (ESA) is associated with adverse events in patients on maintenance hemodialysis (MHD). However, it has not been determined whether higher iron storage is associated with an improved response, including better survival,...

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Bibliographic Details
Published in:PloS one 2016-03, Vol.11 (3), p.e0147328-e0147328
Main Authors: Kuragano, Takahiro, Kitamura, Kenichiro, Matsumura, Osamu, Matsuda, Akihiko, Hara, Taiga, Kiyomoto, Hideyasu, Murata, Toshiaki, Fujimoto, Shouichi, Hase, Hiroki, Joki, Nobuhiko, Fukatsu, Atushi, Inoue, Toru, Itakura, Yukihiro, Nakanishi, Takeshi
Format: Article
Language:English
Subjects:
Aged
Anemia
Angina pectoris
Angiotensin
Angiotensin-converting enzyme inhibitors
Biology and Life Sciences
Blood
Cholesterol
Complications and side effects
Dialysis
Dosage and administration
Drug dosages
Enzymes
Erythropoiesis
Female
Ferritin
Ferritins - blood
Heart attacks
Heart failure
Hematinics
Hematinics - adverse effects
Hematinics - therapeutic use
Hemodialysis
Hemoglobin
Hemoglobins - metabolism
Hospitals
Humans
Internal medicine
Intravenous administration
Iron
Iron - metabolism
Kidney diseases
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - therapy
Magnetohydrodynamics
Male
Medical prognosis
Medicine
Medicine and Health Sciences
Metabolism
Middle Aged
Mortality
Nephrology
Patients
Peptidyl-dipeptidase A
Physical sciences
Physiological aspects
Renal Dialysis
Research and Analysis Methods
Serum albumin
Storage
Systematic review
Transferrin
Transferrin - metabolism
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Summary:It has been reported that hyporesponsiveness to erythropoiesis-stimulating agent (ESA) is associated with adverse events in patients on maintenance hemodialysis (MHD). However, it has not been determined whether higher iron storage is associated with an improved response, including better survival, to ESA. We measured serum ferritin, hemoglobin (Hb), and transferrin saturation (TSAT) levels every three months for two years in 1,095 MHD patients. The weekly dose of ESA to Hb ratio was also calculated as an index of ESA responsiveness (ERI). A significant correlation (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0147328