Maternal Serum C-Reactive Protein in Women with Preterm Prelabor Rupture of Membranes

This study evaluated maternal C-reactive protein (CRP) as a predictor of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) in women with preterm prelabor rupture of the membranes (PPROM) before and after 32 weeks of gestation. This study was a prospective obser...

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Bibliographic Details
Published in:PloS one 2016, Vol.11 (3), p.e0150217-e0150217
Main Authors: Stepan, Martin, Cobo, Teresa, Musilova, Ivana, Hornychova, Helena, Jacobsson, Bo, Kacerovsky, Marian
Format: Article
Language:English
Subjects:
Adult
Age
Age Distribution
Amniocentesis
Amniotic fluid
Amniotic Fluid - microbiology
Bacteria
Bacterial Load
Biology and Life Sciences
Biomedical research
C-reactive protein
C-Reactive Protein - metabolism
Chlamydia trachomatis
Chorioamnionitis
Chorioamnionitis - blood
Female
Fetal Membranes, Premature Rupture - blood
Gene amplification
Gestation
Gynecology
histological chorioamnionitis
Hospitals
Humans
Infant, Newborn
infection
Infections
Inflammation
inflammatory response
interleukin-6
Labor, Obstetric - blood
Likelihood ratio
Medicine
Medicine and Health Sciences
Membranes
microbial invasion
Microorganisms
Models, Biological
Obstetric Labor, Premature - blood
Obstetrics
Obstetrics, Gynecology and Reproductive Medicine
pregnancies
Pregnancy
premature
prevalence
Proteins
Public health
Reproduktionsmedicin och gynekologi
Research and Analysis Methods
rRNA 16S
Rupture
Sexually transmitted diseases
Systematic review
Ultrasonic imaging
Umbilical cord
Ureaplasma - physiology
Womens health
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Summary:This study evaluated maternal C-reactive protein (CRP) as a predictor of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) in women with preterm prelabor rupture of the membranes (PPROM) before and after 32 weeks of gestation. This study was a prospective observational cohort study of 386 women. Maternal serum CRP concentrations were evaluated, and amniotic fluid samples were obtained via transabdominal amniocentesis at the time of admission. Placentas underwent histopathological examination after delivery. MIAC was defined based on a positive PCR for Ureaplasma species, Mycoplasma hominis and Chlamydia trachomatis and/or positive 16S rRNA gene amplification. HCA was defined based on the Salafia classification. Maternal CRP was significantly higher in women with MIAC and HCA (median 9.0 mg/l) than in women with HCA alone (median 6.9 mg/l), MIAC alone (median 7.4 mg/l) and without MIAC or HCA (median 4.5 mg/l) (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0150217