Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study

• Published in: PloS one 2016-02, Vol.11 (2), p.e0147565-e0147565
• Main Authors: Teraguchi, Masatoshi, Yoshimura, Noriko, Hashizume, Hiroshi, Muraki, Shigeyuki, Yamada, Hiroshi, Oka, Hiroyuki, Minamide, Akihito, Ishimoto, Yuyu, Nagata, Keiji, Kagotani, Ryohei, Tanaka, Sakae, Kawaguchi, Hiroshi, Nakamura, Kozo, Akune, Toru, Yoshida, Munehito
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol use; Analysis; Arthritis; Atherosclerosis; Back pain; Biology and Life Sciences; Biomarkers; Blood Pressure; Body weight; Confidence intervals; Criteria; Degeneration; Diabetes; Disease; Disease prevention; Dyslipidemia; Dyslipidemias; Female; Glucose; Glucose Intolerance; Glucose tolerance; Hemoglobin; Humans; Hypertension; Intervertebral Disc Degeneration - diagnosis; Intervertebral Disc Degeneration - epidemiology; Intervertebral Disc Degeneration - etiology; Intervertebral discs; Magnetic resonance; Magnetic resonance imaging; Male; Medicine; Medicine and Health Sciences; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - epidemiology; Metabolic syndrome X; Middle Aged; Multivariate analysis; NMR; Nuclear magnetic resonance; Obesity; Odds Ratio; Overweight; People and Places; People with disabilities; Population; Prevalence; Regression analysis; Rehabilitation; Research and Analysis Methods; Risk factors; Spine; Spine (lumbar); Spine - metabolism; Spine - pathology; Statistical analysis; Studies; Surgery; Thorax; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0147565

The objective of the present study was to examine the associations between metabolic syndrome (MS) components, such as overweight (OW), hypertension (HT), dyslipidemia (DL), and impaired glucose tolerance (IGT), and intervertebral disc degeneration (DD). The present study included 928 participants (308 men, 620 women) of the 1,011 participants in the Wakayama Spine Study. DD on magnetic resonance imaging was classified according to the Pfirrmann system. OW, HT, DL, and IGT were assessed using the criteria of the Examination Committee of Criteria for MS in Japan. Multivariable logistic regression analysis revealed that OW was significantly associated with cervical, thoracic, and lumbar DD (cervical: odds ratio [OR], 1.28; 95% confidence interval [CI], 0.92-1.78; thoracic: OR, 1.75; 95% CI, 1.24-2.51; lumbar: OR, 1.87; 95% CI, 1.06-3.48). HT and IGT were significantly associated with thoracic DD (HT: OR, 1.54; 95% CI, 1.09-2.18; IGT: OR, 1.65; 95% CI, 1.12-2.48). Furthermore, subjects with 1 or more MS components had a higher OR for thoracic DD compared with those without MS components (vs. no component; 1 component: OR, 1.58; 95% CI, 1.03-2.42; 2 components: OR, 2.60; 95% CI, 1.62-4.20; ≥3 components: OR, 2.62; 95% CI, 1.42-5.00). MS components were significantly associated with thoracic DD. Furthermore, accumulation of MS components significantly increased the OR for thoracic DD. These findings support the need for further studies of the effects of metabolic abnormality on DD.