Serum LBP Is Associated with Insulin Resistance in Women with PCOS

Lipopolysaccharide-binding protein (LBP) is closely associated with many metabolic disorders. However, no study has been done to explore the relationship between LBP and polycystic ovary syndrome (PCOS). The objective of this study was to investigate whether the serum LBP level is elevated and assoc...

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Bibliographic Details
Published in:PloS one 2016-01, Vol.11 (1), p.e0145337-e0145337
Main Authors: Zhu, Qibo, Zhou, Huang, Zhang, Aipin, Gao, Rufei, Yang, Shumin, Zhao, Changhong, Wang, Yue, Hu, Jinbo, Goswami, Richa, Gong, Lilin, Li, Qifu
Format: Article
Language:English
Subjects:
Acute-Phase Proteins
Adult
Biology and Life Sciences
Body mass
Body Mass Index
Body size
Body weight
C-reactive protein
Carrier Proteins - blood
Case-Control Studies
Cholesterol
Cross-Sectional Studies
Fasting
Female
Globulins
Glucose
High density lipoprotein
Hormones
Humans
Insulin
Insulin Resistance
Linear Models
Lipids
Lipopolysaccharide-binding protein
Low density lipoprotein
Medicine and Health Sciences
Membrane Glycoproteins - blood
Metabolic disorders
Obesity
Obesity - blood
Obesity - physiopathology
Overweight
Overweight - blood
Polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - physiopathology
Regression analysis
Sex
Sex hormones
Testosterone
Triglycerides
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Summary:Lipopolysaccharide-binding protein (LBP) is closely associated with many metabolic disorders. However, no study has been done to explore the relationship between LBP and polycystic ovary syndrome (PCOS). The objective of this study was to investigate whether the serum LBP level is elevated and associated with insulin resistance (IR) in PCOS. In this cross-sectional study, 117 PCOS patients and 121 age-matched controls were recruited. Hyperinsulinemic-euglycemic clamp was performed with an expression of M value for insulin sensitivity. Fasting serum samples were collected to detect LBP, lipids, insulin, sex hormones and high sensitive C reactive protein (hs-CRP). Pearson's correlation and multiple linear regression was used to analyze the associations between M value and LBP level. The study was performed in a clinical research center. Compared with controls, PCOS subjects had a significantly higher LBP concentration (33.03±14.59 vs. 24.35±10.31 μg/ml, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0145337