Impact of Elevated Hemoglobin and Serum Protein on Vasovagal Reaction from Blood Donation

We conducted a cross-sectional study to elucidate factors contributing to vasovagal reaction (VVR), the most frequent side effect following whole blood and apheresis donations. Complications recorded at the collection sites after voluntary donations by the Japanese Red Cross Tokyo Blood Center (JRC)...

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Bibliographic Details
Published in:PloS one 2016-02, Vol.11 (2), p.e0148854-e0148854
Main Authors: Odajima, Takeshi, Takanashi, Minoko, Sugimori, Hiroki, Tanba, Taiko, Yoshinaga, Kentaro, Motoji, Toshiko, Munakata, Masaya, Nakajima, Kazunori, Minami, Mutsuhiko
Format: Article
Language:English
Subjects:
Adult
Age
Albumin
Apheresis
Biology and Life Sciences
Blood
Blood & organ donations
Blood donation
Blood Donors
Blood Pressure
Blood Proteins
Body mass
Body mass index
Case-Control Studies
Complications
Epidemiology
Female
Health care
Hematology
Hemoglobin
Hemoglobins
Humans
Male
Males
Measurement
Medicine and Health Sciences
Odds Ratio
Physical Sciences
Physiological aspects
Plasma
Regression analysis
Regression models
Research and Analysis Methods
Sex
Sex Factors
Statistical analysis
Syncope, Vasovagal - blood
Syncope, Vasovagal - etiology
Young Adult
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Summary:We conducted a cross-sectional study to elucidate factors contributing to vasovagal reaction (VVR), the most frequent side effect following whole blood and apheresis donations. Complications recorded at the collection sites after voluntary donations by the Japanese Red Cross Tokyo Blood Center (JRC), in the 2006 and 2007 fiscal years, were analyzed by both univariate analysis and the multivariate conditional logistic regression model. Of 1,119,716 blood donations over the full two years, complications were recorded for 13,320 donations (1.18%), among which 67% were VVR. There were 4,303 VVR cases which had sufficient information and could be used for this study. For each VVR case, two sex- and age-matched controls (n = 8,606) were randomly selected from the donors without complications. Age, sex, body mass index (BMI), predonation blood pressure, pulse and blood test results, including total protein, albumin, and hemoglobin, were compared between the VVR group and the control group. In univariate analysis, the VVR group was significantly younger, with a lower BMI, higher blood pressure and higher blood protein and hemoglobin levels than the control group (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0148854