Maternal Prenatal Positive Affect, Depressive and Anxiety Symptoms and Birth Outcomes: The PREDO Study

• Published in: PloS one 2016-02, Vol.11 (2), p.e0150058-e0150058
• Main Authors: Pesonen, Anu-Katriina, Lahti, Marius, Kuusinen, Tiina, Tuovinen, Soile, Villa, Pia, Hämäläinen, Esa, Laivuori, Hannele, Kajantie, Eero, Räikkönen, Katri
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Affect - physiology; Anxiety; Anxiety - psychology; Attitudes; Behavioral sciences; Biology and Life Sciences; Birth weight; Birth Weight - physiology; Childbirth & labor; Complications and side effects; Delivery scheduling; Depression (Mood disorder); Depression - psychology; Emotions; Epidemiology; Epigenetics; Female; Fetal development; Fetuses; Gestation; Gestational Age; Gynecology; Health risk assessment; Hospitals; Humans; Hypotheses; Infant, Newborn; Male; Medical records; Medicine and Health Sciences; Mental depression; Middle Aged; Mothers; Mothers - psychology; Obstetrics; Preeclampsia; Pregnancy; Pregnancy Complications - psychology; Pregnancy Outcome; Pregnant women; Pregnant Women - psychology; Premature birth; Psychological aspects; Social Sciences; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0150058

We investigated whether maternal prenatal emotions are associated with gestational length and birth weight in the large PREDO Study with multiple measurement points of emotions during gestation. Altogether 3376 pregnant women self-assessed their positive affect (PA, Positive and Negative Affect Schedule) and depressive (Center for Epidemiologic Studies Depression Scale, CES-D) and anxiety (Spielberger State Anxiety Scale, STAI) symptoms up to 14 times during gestation. Birth characteristics were derived from the National Birth Register and from medical records. One standard deviation (SD) unit higher PA during the third pregnancy trimester was associated with a 0.05 SD unit longer gestational length, whereas one SD unit higher CES-D and STAI scores during the third trimester were associated with 0.04-0.05 SD unit shorter gestational lengths (P-values ≤ 0.02), corresponding to only 0.1-0.2% of the variation in gestational length. Higher PA during the third trimester was associated with a significantly decreased risk for preterm (< 37 weeks) delivery (for each SD unit higher positive affect, odds ratio was 0.8-fold (P = 0.02). Mothers with preterm delivery showed a decline in PA and an increase in CES-D and STAI during eight weeks prior to delivery. Post-term birth (≥ 42 weeks), birth weight and fetal growth were not associated with maternal prenatal emotions. This study with 14 measurements of maternal emotions during pregnancy show modest effects of prenatal emotions during the third pregnancy trimester, particularly in the weeks close to delivery, on gestational length. From the clinical perspective, the effects were negligible. No associations were detected between prenatal emotions and birth weight.