Pathologic Evaluation of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection at the Maternal-Fetal Interface of Late Gestation Pregnant Gilts

The pathogenesis of fetal death caused by porcine reproductive and respiratory syndrome virus (PRRSV) remains unclear. The objective of this study was to improve our understanding of the pathogenesis by assessing potential relationships between specific histopathological lesions and PRRSV RNA concen...

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Bibliographic Details
Published in:PloS one 2016-03, Vol.11 (3), p.e0151198-e0151198
Main Authors: Novakovic, Predrag, Harding, John C S, Al-Dissi, Ahmad N, Ladinig, Andrea, Detmer, Susan E
Format: Article
Language:English
Subjects:
Animals
Biology and Life Sciences
Development and progression
Disease
Drug dosages
Endometriosis - metabolism
Endometriosis - pathology
Endometriosis - virology
Endometrium
Female
Fetus - embryology
Fetus - pathology
Fetus - virology
Fetuses
Genetic aspects
Genotypes
Gestation
Hogs
Identification and classification
Infections
Lesions
Meconium
Medicine and Health Sciences
Mutation
Pathogenesis
Pathology
Placenta - metabolism
Placenta - pathology
Placenta - virology
Porcine Reproductive and Respiratory Syndrome - metabolism
Porcine Reproductive and Respiratory Syndrome - pathology
Porcine respiratory and reproductive syndrome virus - metabolism
Pregnancy
Pregnancy Complications, Infectious - metabolism
Pregnancy Complications, Infectious - pathology
Pregnancy Complications, Infectious - virology
Ribonucleic acid
RNA
RNA virus infections
RNA, Viral - metabolism
Staining
Swine - metabolism
Swine - virology
Swine diseases
Thymus
Thymus Gland - embryology
Thymus Gland - pathology
Thymus Gland - virology
Umbilical cord
Vasculitis
Vasculitis - metabolism
Vasculitis - pathology
Vasculitis - virology
Veterinary colleges
Veterinary medicine
Virulence (Microbiology)
Viruses
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Summary:The pathogenesis of fetal death caused by porcine reproductive and respiratory syndrome virus (PRRSV) remains unclear. The objective of this study was to improve our understanding of the pathogenesis by assessing potential relationships between specific histopathological lesions and PRRSV RNA concentration in the fetuses and the maternal-fetal interface. Pregnant gilts were inoculated with PRRSV (n = 114) or sham inoculated (n = 19) at 85±1 days of gestation. Dams and their litters were humanely euthanized and necropsied 21 days later. PRRSV RNA concentration was measured by qRT-PCR in the maternal-fetal interface and fetal thymus (n = 1391). Presence of fetal lesions was positively related to PRRSV RNA concentration in the maternal-fetal interface and fetal thymus (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0151198