Bronchiectasis as a Comorbidity of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

• Published in: PloS one 2016-03, Vol.11 (3), p.e0150532
• Main Authors: Du, Qingxia, Jin, Jianmin, Liu, Xiaofang, Sun, Yongchang
• Format: Article
• Language: English
• Subjects: Aged; Biology and Life Sciences; Bronchiectasis; Bronchiectasis - complications; Bronchiectasis - diagnostic imaging; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Cohort Studies; Comorbidity; Computed tomography; Development and progression; Health aspects; Humans; Literature reviews; Lung diseases; Medical ethics; Medicine and Health Sciences; Meta-analysis; Microorganisms; Middle Aged; Mortality; Obstructive lung disease; Patient outcomes; Patients; Physical Sciences; Pseudomonas aeruginosa; Pulmonary Disease, Chronic Obstructive - complications; Research and Analysis Methods; Respiratory tract; Systematic review; Thorax; Tomography, X-Ray Computed
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0150532

Bronchiectasis revealed by chest computed tomography in COPD patients and its comorbid effect on prognosis have not been addressed by large-sized studies. Understanding the presence of bronchiectasis in COPD is important for future intervention and preventing disease progression. Observational studies were identified from electronic literature searches in Cochrane library, PubMed, ScienceDirect databases, American Thoracic Society and European Respiratory Society meeting abstracts. A systematic review and meta-analysis of studies was performed to summarize the factors associated with bronchiectasis in COPD patients. Primary outcomes included the risks for exacerbation frequency, isolation of a potentially pathogenic microorganism, severe airway obstruction and mortality. Odds ratios (ORs) were pooled by random effects models. Fourteen observational studies were eligible for the study. Compared with COPD without bronchiectasis, comorbid bronchiectasis in COPD increased the risk of exacerbation (1.97, 95% CI, 1.29-3.00), isolation of a potentially pathogenic microorganism (4.11, 95%CI, 2.16-7.82), severe airway obstruction (1.31, 95% CI, 1.09-1.58) and mortality (1.96, 95% CI, 1.04-3.70). The presence of bronchiectasis in patients with COPD was associated with exacerbation frequency, isolation of a potentially pathogenic microorganism, severe airway obstruction and mortality.