Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men

A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested case-control study, serum-25-hydroxyvitamin D (s-25(OH)D) was positively associated with incid...

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Bibliographic Details
Published in:PloS one 2016-03, Vol.11 (3), p.e0151441-e0151441
Main Authors: Meyer, Haakon E, Støer, Nathalie C, Samuelsen, Sven O, Blomhoff, Rune, Robsahm, Trude E, Brustad, Magritt, Giovannucci, Edward L, Bjørge, Tone
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Adult
Aged
Aged, 80 and over
Animals
Biology and Life Sciences
Cancer
Case-Control Studies
Cause of Death
Clinical trials
Cohort Studies
Confidence intervals
Exercise
Hazards
Health aspects
Health risk assessment
Health risks
Helsefag: 800
Humans
Male
Medical diagnosis
Medicin och hälsovetenskap
Medicine and Health Sciences
Medisinske Fag: 700
Men
Middle Aged
Mortality
Norway
Observational studies
People and Places
Physical sciences
Population studies
Proportional Hazards Models
Prostate cancer
Prostatic Neoplasms - blood
Prostatic Neoplasms - mortality
Research and Analysis Methods
Risk Assessment - methods
Risk Assessment - statistics & numerical data
Risk Factors
Samfunnsmedisin, sosialmedisin: 801
Statistical analysis
Studies
Survival Rate
Systematic review
Time Factors
VDP
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested case-control study, serum-25-hydroxyvitamin D (s-25(OH)D) was positively associated with incident prostate cancer. Based on the same study population, the primary aim of the present study was to investigate the association between s-25(OH)D and total mortality. Men participating in population based health screenings during 1981-1991 and enrolled in a nested case-control study were followed throughout 2007 with respect to all-cause and cause-specific mortality. Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using Cox proportional hazards regression. In men with prostate cancer (n = 2282), there was a significant inverse association between s-25(OH)D and total mortality after controlling for potential confounders (HR = 1.25 (95% CI 1.05-1.50), s-25(OH)D
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0151441