Augmented Pain Processing in Primary and Secondary Somatosensory Cortex in Fibromyalgia: A Magnetoencephalography Study Using Intra-Epidermal Electrical Stimulation

• Published in: PloS one 2016-03, Vol.11 (3), p.e0151776-e0151776
• Main Authors: Lim, Manyoel, Roosink, Meyke, Kim, June Sic, Kim, Hye Won, Lee, Eun Bong, Son, Kyeong Min, Kim, Hyun Ah, Chung, Chun Kee
• Format: Article
• Language: English
• Subjects: Adult; Biology and Life Sciences; Brain Mapping; Brain research; Care and treatment; Complications and side effects; Cortex (somatosensory); Cortex (temporal); Depression, Mental; Electric Stimulation; Electrical stimuli; Equivalence; Family medical history; Female; Fibromyalgia; Fibromyalgia - physiopathology; Hospitals; Humans; Internal medicine; Magnetoencephalography; Mechanical stimuli; Medicine; Medicine and Health Sciences; Middle Aged; Muscles; Neurosciences; NMR; Nuclear magnetic resonance; Pain; Pain Measurement; Patients; Ratings; Research and Analysis Methods; Rheumatology; Risk factors; Sensory testing; Social Sciences; Somatosensory Cortex - physiopathology; Somatosensory system; Spinal cord; Stimulation; Stimuli; Studies; Trapezius muscle
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0151776

The aim of this study was to investigate augmented pain processing in the cortical somatosensory system in patients with fibromyalgia (FM). Cortical evoked responses were recorded in FM (n = 19) and healthy subjects (n = 21) using magnetoencephalography after noxious intra-epidermal electrical stimulation (IES) of the hand dorsum (pain rating 6 on a numeric rating scale, perceptually-equivalent). In addition, healthy subjects were stimulated using the amplitude corresponding to the average stimulus intensity rated 6 in patients with FM (intensity-equivalent). Quantitative sensory testing was performed on the hand dorsum or thenar muscle (neutral site) and over the trapezius muscle (tender point), using IES (thresholds, ratings, temporal summation of pain, stimulus-response curve) and mechanical stimuli (threshold, ratings). Increased amplitude of cortical responses was found in patients with FM as compared to healthy subjects. These included the contralateral primary (S1) and bilateral secondary somatosensory cortices (S2) in response to intensity-equivalent stimuli and the contralateral S1 and S2 in response to perceptually-equivalent stimuli. The amplitude of the contralateral S2 response in patients with FM was positively correlated with average pain intensity over the last week. Quantitative sensory testing results showed that patients with FM were more sensitive to painful IES as well as to mechanical stimulation, regardless of whether the stimulation site was the hand or the trapezius muscle. Interestingly, the slope of the stimulus-response relationship as well as temporal summation of pain in response to IES was not different between groups. Together, these results suggest that the observed pain augmentation in response to IES in patients with FM could be due to sensitization or disinhibition of the cortical somatosensory system. Since the S2 has been shown to play a role in higher-order functions, further studies are needed to clarify the role of augmented S2 response in clinical characteristics of FM.