Preterm Birth and Low Birth Weight after In Utero Exposure to Antiretrovirals Initiated during Pregnancy in Yaoundé, Cameroon

Effects of antiretroviral therapy (ART) on birth outcomes remain controversial. To assess the impact of antenatal exposure to ART on the occurrence of preterm birth (PTB) and low birth weight (LBW). A cross-sectional study conducted at the Essos Hospital Center in Yaounde from 2008 to 2011 among HIV...

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Bibliographic Details
Published in:PloS one 2016-03, Vol.11 (3), p.e0150565-e0150565
Main Authors: Njom Nlend, Anne Esther, Nga Motazé, Annie, Moyo Tetang, Suzie, Zeudja, Cécile, Ngantcha, Marcus, Tejiokem, Mathurin
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Antiviral agents
Biology and Life Sciences
Birth weight
Cameroon - epidemiology
CD4 antigen
Childbirth & labor
Exposure
Female
Health risk assessment
HIV
Human immunodeficiency virus
Humans
Infant
Infant, Low Birth Weight
Infants
Intrauterine exposure
Low-birth-weight
Medicine and Health Sciences
Mothers
Multivariate Analysis
Nevirapine
Pregnancy
Premature birth
Premature Birth - epidemiology
Premature Birth - etiology
Prenatal Exposure Delayed Effects - epidemiology
Prenatal Exposure Delayed Effects - etiology
Prevalence
Proteinase inhibitors
Regression analysis
Statistical analysis
Womens health
Young Adult
Zidovudine
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Summary:Effects of antiretroviral therapy (ART) on birth outcomes remain controversial. To assess the impact of antenatal exposure to ART on the occurrence of preterm birth (PTB) and low birth weight (LBW). A cross-sectional study conducted at the Essos Hospital Center in Yaounde from 2008 to 2011 among HIV vertically exposed infants with two distinct maternal antiretroviral experiences: monotherapy group (Zidovudine, ZDV) and the combination ART group (cART). Mothers already receiving cART before pregnancy were ineligible. In both groups, events of PTB (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0150565