Enhanced Diabetes Susceptibility in Community Dwelling Han Elders Carrying the Apolipoprotein E 3/3 Genotype

Despite Apolipoprotein E (ApoE) being one of the main apolipoproteins in the blood, the association between its genotype and the high cholesterol or blood glucose levels commonly seen in clinical practice is inconclusive. Such research is also lacking in the Han population. The aim of this study was...

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Published in:PloS one 2016-03, Vol.11 (3), p.e0151336-e0151336
Main Authors: Ban, Chun-Xia, Zhong, Li, Wang, Tao, Zhu, Min-Jie, Wang, Jing-Hua, Zhang, Zhen-Lian, Wang, Zhe, Su, Ning, Liu, Yuan-Yuan, Shi, Yan-Chen, Xiao, Shi-Fu, Li, Xia
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alleles
Analysis
Apolipoprotein E3 - genetics
Apolipoproteins
Biology and Life Sciences
Blood
Blood Glucose - metabolism
Blood pressure
Cardiovascular disease
Cholesterol
Cognitive ability
Communities
Correlation
Dementia disorders
Diabetes mellitus
Diabetes Mellitus - blood
Diabetes Mellitus - genetics
Elderly
Ethnic Groups - genetics
Fasting
Female
Genetic aspects
Genetic Predisposition to Disease
Genotype & phenotype
Genotypes
Geriatrics
Glucose
Health aspects
Health risk assessment
Heterozygote
Humans
Hypertension
Independent Living
Laboratory testing
Lipids
Low density lipoprotein
Male
Medicine and Health Sciences
Middle Aged
Minority & ethnic groups
Older people
People and places
Population (statistical)
Residential density
Risk factors
Statistical analysis
Statistical significance
Triglycerides
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cited_by cdi_FETCH-LOGICAL-c692t-b21341bbba1f02fbf0dfba599529d58daf9a097e5dafa9d3f6cd7922cc8ea8673
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container_title PloS one
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creator Ban, Chun-Xia
Zhong, Li
Wang, Tao
Zhu, Min-Jie
Wang, Jing-Hua
Zhang, Zhen-Lian
Wang, Zhe
Su, Ning
Liu, Yuan-Yuan
Shi, Yan-Chen
Xiao, Shi-Fu
Li, Xia
description Despite Apolipoprotein E (ApoE) being one of the main apolipoproteins in the blood, the association between its genotype and the high cholesterol or blood glucose levels commonly seen in clinical practice is inconclusive. Such research is also lacking in the Han population. The aim of this study was to investigate the association between APOE genotype, diabetes, and plasma glucose and lipid levels. We included 243 community-dwelling elderly residents in this study. Participant APOE genotypes were assessed and were simultaneously tested for weight, height, blood glucose, triglycerides, cholesterol, and high- and low-density lipoprotein. In addition, gender, age, years of education, cognitive function, and medical history was recorded. Subjects were divided into 3 groups based on APOE genotype: APOE ε2 group (ε2/ε2 and ε2/ε3), APOE ε3 group (ε3/ε3), and APOE ε4 group (ε2/ε4, ε3/ε4 and ε4/ε4). Comparisons between groups were conducted for the incidence of diabetes, high blood pressure, and dementia, as well as for differences in body-mass index, fasting plasma glucose, and blood lipids. The APOE ε3/ε3 genotype exhibited the highest frequency (70.4%) among the subjects. Participants in the APOE ε3 group demonstrated significantly higher levels of fasting plasma glucose than those in the APOE ε2 and APOE ε4 groups (P
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Such research is also lacking in the Han population. The aim of this study was to investigate the association between APOE genotype, diabetes, and plasma glucose and lipid levels. We included 243 community-dwelling elderly residents in this study. Participant APOE genotypes were assessed and were simultaneously tested for weight, height, blood glucose, triglycerides, cholesterol, and high- and low-density lipoprotein. In addition, gender, age, years of education, cognitive function, and medical history was recorded. Subjects were divided into 3 groups based on APOE genotype: APOE ε2 group (ε2/ε2 and ε2/ε3), APOE ε3 group (ε3/ε3), and APOE ε4 group (ε2/ε4, ε3/ε4 and ε4/ε4). Comparisons between groups were conducted for the incidence of diabetes, high blood pressure, and dementia, as well as for differences in body-mass index, fasting plasma glucose, and blood lipids. The APOE ε3/ε3 genotype exhibited the highest frequency (70.4%) among the subjects. Participants in the APOE ε3 group demonstrated significantly higher levels of fasting plasma glucose than those in the APOE ε2 and APOE ε4 groups (P&lt;0.05). The APOE ε3 group had slightly higher abnormal fasting plasma glucose values than did the APOE ε2 group (P = 0.065). Furthermore, the APOE3 genotype was significantly correlated with both fasting plasma glucose level and glucose abnormality (P&lt; 0.05) and trended toward statistically significant correlation with diabetes (P = 0.082). The correlation between APOE2 and low low-density lipoprotein levels also approached statistical significance (P = 0.052). 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Participants in the APOE ε3 group demonstrated significantly higher levels of fasting plasma glucose than those in the APOE ε2 and APOE ε4 groups (P&lt;0.05). The APOE ε3 group had slightly higher abnormal fasting plasma glucose values than did the APOE ε2 group (P = 0.065). Furthermore, the APOE3 genotype was significantly correlated with both fasting plasma glucose level and glucose abnormality (P&lt; 0.05) and trended toward statistically significant correlation with diabetes (P = 0.082). The correlation between APOE2 and low low-density lipoprotein levels also approached statistical significance (P = 0.052). Thus, elderly community dwelling residents of Han ethnicity carrying the APOE ε3/ε3 genotype might have higher plasma glucose levels and a higher occurrence of diabetes.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Analysis</subject><subject>Apolipoprotein E3 - genetics</subject><subject>Apolipoproteins</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood Glucose - metabolism</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Cognitive ability</subject><subject>Communities</subject><subject>Correlation</subject><subject>Dementia disorders</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - genetics</subject><subject>Elderly</subject><subject>Ethnic Groups - genetics</subject><subject>Fasting</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype &amp; 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Such research is also lacking in the Han population. The aim of this study was to investigate the association between APOE genotype, diabetes, and plasma glucose and lipid levels. We included 243 community-dwelling elderly residents in this study. Participant APOE genotypes were assessed and were simultaneously tested for weight, height, blood glucose, triglycerides, cholesterol, and high- and low-density lipoprotein. In addition, gender, age, years of education, cognitive function, and medical history was recorded. Subjects were divided into 3 groups based on APOE genotype: APOE ε2 group (ε2/ε2 and ε2/ε3), APOE ε3 group (ε3/ε3), and APOE ε4 group (ε2/ε4, ε3/ε4 and ε4/ε4). Comparisons between groups were conducted for the incidence of diabetes, high blood pressure, and dementia, as well as for differences in body-mass index, fasting plasma glucose, and blood lipids. The APOE ε3/ε3 genotype exhibited the highest frequency (70.4%) among the subjects. Participants in the APOE ε3 group demonstrated significantly higher levels of fasting plasma glucose than those in the APOE ε2 and APOE ε4 groups (P&lt;0.05). The APOE ε3 group had slightly higher abnormal fasting plasma glucose values than did the APOE ε2 group (P = 0.065). Furthermore, the APOE3 genotype was significantly correlated with both fasting plasma glucose level and glucose abnormality (P&lt; 0.05) and trended toward statistically significant correlation with diabetes (P = 0.082). The correlation between APOE2 and low low-density lipoprotein levels also approached statistical significance (P = 0.052). Thus, elderly community dwelling residents of Han ethnicity carrying the APOE ε3/ε3 genotype might have higher plasma glucose levels and a higher occurrence of diabetes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26998902</pmid><doi>10.1371/journal.pone.0151336</doi><oa>free_for_read</oa></addata></record>
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subjects Aged
Aged, 80 and over
Alleles
Analysis
Apolipoprotein E3 - genetics
Apolipoproteins
Biology and Life Sciences
Blood
Blood Glucose - metabolism
Blood pressure
Cardiovascular disease
Cholesterol
Cognitive ability
Communities
Correlation
Dementia disorders
Diabetes mellitus
Diabetes Mellitus - blood
Diabetes Mellitus - genetics
Elderly
Ethnic Groups - genetics
Fasting
Female
Genetic aspects
Genetic Predisposition to Disease
Genotype & phenotype
Genotypes
Geriatrics
Glucose
Health aspects
Health risk assessment
Heterozygote
Humans
Hypertension
Independent Living
Laboratory testing
Lipids
Low density lipoprotein
Male
Medicine and Health Sciences
Middle Aged
Minority & ethnic groups
Older people
People and places
Population (statistical)
Residential density
Risk factors
Statistical analysis
Statistical significance
Triglycerides
title Enhanced Diabetes Susceptibility in Community Dwelling Han Elders Carrying the Apolipoprotein E 3/3 Genotype
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