Increased Intraocular Pressure and Hyperglycemic Level in Diabetic Patients

To determine whether hyperglycemic levels as determined from high hemoglobin A1c (HbA1c) levels influence intraocular pressure (IOP) in patients with non-proliferative diabetic retinopathy (NPDR). A retrospective chart review was performed on subjects with a diagnosis of NPDR and a corresponding HbA...

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Bibliographic Details
Published in:PloS one 2016-03, Vol.11 (3), p.e0151833-e0151833
Main Authors: Hymowitz, Maggie B, Chang, Donny, Feinberg, Edward B, Roy, Sayon
Format: Article
Language:English
Subjects:
Analysis
Biology and life sciences
Care and treatment
Computer and Information Sciences
Confidence intervals
Diabetes
Diabetes mellitus
Diabetes Mellitus - blood
Diabetes Mellitus - pathology
Diabetic Retinopathy - blood
Diabetic Retinopathy - pathology
Diagnosis
Extracellular matrix
Female
Glaucoma
Glucose
Glycated Hemoglobin A - physiology
Hemoglobin
Humans
Hyperglycemia
Hyperglycemia - blood
Hyperglycemia - pathology
Influence
Intraocular pressure
Intraocular Pressure - physiology
Male
Medical diagnosis
Medicine
Medicine and health sciences
Middle Aged
Patients
Physical Sciences
Population
Pressure
Regression analysis
Retinopathy
Retrospective Studies
Risk factors
Statistical analysis
Steroid hormones
Steroids
Studies
Tonometry, Ocular
Type 2 diabetes
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Summary:To determine whether hyperglycemic levels as determined from high hemoglobin A1c (HbA1c) levels influence intraocular pressure (IOP) in patients with non-proliferative diabetic retinopathy (NPDR). A retrospective chart review was performed on subjects with a diagnosis of NPDR and a corresponding HbA1c level measured within 90 days before or after an IOP measurement over a two-year period. Exclusion criteria included a diagnosis of glaucoma or treatment with IOP lowering medications or oral or topical steroids. Using 14.5mmHg as a baseline mean value for IOP, 42 subjects had an IOP < 14.5mmHg and mean HbA1c of 8.1±1.1, while 72 subjects had an IOP ≥ 14.5mmHg and a mean HbA1c of 9.0±2.1. Although there was an overlap in the confidence intervals, a significant difference (P = 0.01) in the mean HbA1c level was observed in regression analysis between the two groups. Importantly, diabetic subjects with elevated HbA1c levels rarely (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0151833