Bone Canopies in Pediatric Renal Osteodystrophy

Pediatric renal osteodystrophy (ROD) is characterized by changes in bone turnover, mineralization, and volume that are brought about by alterations in bone resorption and formation. The resorptive and formative surfaces on the cancellous bone are separated from the marrow cavity by canopies consisti...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2016-04, Vol.11 (4), p.e0152871-e0152871
Main Authors: Pereira, Renata C, Andersen, Thomas L, Friedman, Peter A, Tumber, Navdeep, Salusky, Isidro B, Wesseling-Perry, Katherine
Format: Article
Language:English
Subjects:
Biocompatibility
Biology and Life Sciences
Biopsy
Bone and Bones - pathology
Bone growth
Bone marrow
Bone remodeling
Bone resorption
Bone turnover
Cancellous bone
Canopies
Child
Chronic Kidney Disease-Mineral and Bone Disorder - pathology
Complications and side effects
Humans
Hyperparathyroidism
Immunoreactivity
Kidney diseases
Kidney transplantation
Machinery and equipment
Medicine
Medicine and Health Sciences
Mineralization
Molecular machines
Musculoskeletal abnormalities
Osteoblasts
Osteodystrophy
Osteogenesis
Osteoporosis
Parathyroid
Parathyroid hormone
Patients
Pediatrics
Phosphatase
Renal osteodystrophy
Risk factors
Signaling
TRANCE protein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pediatric renal osteodystrophy (ROD) is characterized by changes in bone turnover, mineralization, and volume that are brought about by alterations in bone resorption and formation. The resorptive and formative surfaces on the cancellous bone are separated from the marrow cavity by canopies consisting of a layer of flat osteoblastic cells. These canopies have been suggested to play a key role in the recruitment of osteoprogenitors during the process of bone remodeling. This study was performed to address the characteristics of the canopies above bone formation and resorption sites and their association with biochemical and bone histomorphometric parameters in 106 pediatric chronic kidney disease (CKD) patients (stage 2-5) across the spectrum of ROD. Canopies in CKD patients often appeared as thickened multilayered canopies, similar to previous reports in patients with primary hyperparathyroidism. This finding contrasts with the thin appearance reported in healthy individuals with normal kidney function. Furthermore, canopies in pediatric CKD patients showed immunoreactivity to the PTH receptor (PTHR1) as well as to the receptor activator of nuclear factor kappa-B ligand (RANKL). The number of surfaces with visible canopy coverage was associated with plasma parathyroid hormone (PTH) levels, bone formation rate, and the extent of remodeling surfaces. Collectively, these data support the conclusion that canopies respond to the elevated PTH levels in CKD and that they possess the molecular machinery necessary to respond to PTH signaling.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0152871