Growth of HIV-Exposed Uninfected Infants in the First 6 Months of Life in South Africa: The IeDEA-SA Collaboration

HIV-exposed uninfected (HEU) infants are a growing population in sub-Saharan Africa especially with the increasing coverage of more effective prevention of mother-to-child transmission (PMTCT) antiretroviral therapy regimens. This study describes the characteristics of South African HEU infants, inv...

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Bibliographic Details
Published in:PloS one 2016-04, Vol.11 (4), p.e0151762-e0151762
Main Authors: Morden, Erna, Technau, Karl-Günter, Giddy, Janet, Maxwell, Nicola, Keiser, Olivia, Davies, Mary-Ann
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adolescent
Adult
AIDS
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Antiviral agents
Biology and Life Sciences
Birth weight
Breast feeding
Breastfeeding & lactation
CD4 antigen
Childbirth & labor
Disease transmission
Drug delivery systems
Drugs
Exposure
Feeding
Female
Follow-Up Studies
Growth Disorders - physiopathology
Growth Disorders - virology
Health aspects
Highly active antiretroviral therapy
HIV
HIV Infections - complications
HIV Infections - prevention & control
HIV Infections - transmission
HIV Infections - virology
HIV-1 - physiology
Human immunodeficiency virus
Humans
Infant
Infant Formula
Infant, Newborn
Infants
Infectious Disease Transmission, Vertical - prevention & control
Male
Medicine and Health Sciences
Mortality
Mothers
People and Places
Physical Sciences
Pregnancy
Pregnancy Complications, Infectious - virology
Prevention
Prognosis
Research and Analysis Methods
Retrospective Studies
Risk factors
Womens health
Young Adult
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Summary:HIV-exposed uninfected (HEU) infants are a growing population in sub-Saharan Africa especially with the increasing coverage of more effective prevention of mother-to-child transmission (PMTCT) antiretroviral therapy regimens. This study describes the characteristics of South African HEU infants, investigates factors impacting birth weight and assesses their growth within the first 28 weeks of life. This is a retrospective cohort based on routine clinical data from two South African PMTCT programmes. Data were collected between 2007 and 2013. Linear regression assessed factors affecting birth weight-for-age z-scores (WAZ) while growth (longitudinal WAZ) was assessed using mixed effects models. We assessed the growth of 2621 HEU infants (median birth WAZ was -0.65 (IQR -1.46; 0.0) and 51% were male). The feeding modalities practised were as follows: 0.5% exclusive breastfeeding, 7.9% breastfeeding with unknown exclusivity, 0.08% mixed breastfeeding and 89.2% formula feeding. Mothers with CD4
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0151762