A Four-Way Comparison of Cardiac Function with Normobaric Normoxia, Normobaric Hypoxia, Hypobaric Hypoxia and Genuine High Altitude

There has been considerable debate as to whether different modalities of simulated hypoxia induce similar cardiac responses. This was a prospective observational study of 14 healthy subjects aged 22-35 years. Echocardiography was performed at rest and at 15 and 120 minutes following two hours exerci...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2016-04, Vol.11 (4), p.e0152868-e0152868
Main Authors: Boos, Christopher John, O'Hara, John Paul, Mellor, Adrian, Hodkinson, Peter David, Tsakirides, Costas, Reeve, Nicola, Gallagher, Liam, Green, Nicholas Donald Charles, Woods, David Richard
Format: Article
Language:English
Subjects:
Acclimatization - physiology
Adaptation
Adult
Aerospace medicine
Altitude
Altitude sickness
Altitude Sickness - physiopathology
Atmospheric Pressure
Aviation
Biology and Life Sciences
Blood pressure
Cardiac output
Cardiac Output - physiology
Cardiology
Comparative analysis
Complications and side effects
Demographics
Demography
Echocardiography
Edema
Exercise
Exercise - physiology
Female
Heart
Heart diseases
Heart failure
Heart rate
High altitude
High-altitude environments
Hospitals
Humans
Hypoxia
Hypoxia - physiopathology
Leisure
Male
Medicine and Health Sciences
Oxygen - metabolism
Physical fitness
Physiological aspects
Physiology
Prospective Studies
Research and Analysis Methods
Rest
Sea level
Studies
Systolic pressure
Vascular Resistance - physiology
Ventricle
Ventricular Function, Right - physiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There has been considerable debate as to whether different modalities of simulated hypoxia induce similar cardiac responses. This was a prospective observational study of 14 healthy subjects aged 22-35 years. Echocardiography was performed at rest and at 15 and 120 minutes following two hours exercise under normobaric normoxia (NN) and under similar PiO2 following genuine high altitude (GHA) at 3,375 m, normobaric hypoxia (NH) and hypobaric hypoxia (HH) to simulate the equivalent hypoxic stimulus to GHA. All 14 subjects completed the experiment at GHA, 11 at NN, 12 under NH, and 6 under HH. The four groups were similar in age, sex and baseline demographics. At baseline rest right ventricular (RV) systolic pressure (RVSP, p = 0.0002), pulmonary vascular resistance (p = 0.0002) and acute mountain sickness (AMS) scores were higher and the SpO2 lower (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0152868