Relative Biological Effectiveness of HZE Particles for Chromosomal Exchanges and Other Surrogate Cancer Risk Endpoints

The biological effects of high charge and energy (HZE) particle exposures are of interest in space radiation protection of astronauts and cosmonauts, and estimating secondary cancer risks for patients undergoing Hadron therapy for primary cancers. The large number of particles types and energies tha...

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Bibliographic Details
Published in:PloS one 2016-04, Vol.11 (4), p.e0153998-e0153998
Main Authors: Cacao, Eliedonna, Hada, Megumi, Saganti, Premkumar B, George, Kerry A, Cucinotta, Francis A
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Animal models
Astronauts
Biological effects
Biology and Life Sciences
Cancer
Cancer genetics
Care and treatment
Cell cycle
Chromosomes
Complications and side effects
Cosmic Radiation
Cosmic rays
Cosmonauts
Dose-Response Relationship, Radiation
Energy charge
Experiments
Exposure
Extraterrestrial radiation
Fibroblasts
Generalized linear models
Genetic aspects
Genetic transformation
Health aspects
Health physics
Health risks
Humans
Lymphocytes
Mathematical models
Medicine and Health Sciences
Mutation
Neoplasms - genetics
Neoplasms - physiopathology
Particulates
Point mutation
Predictions
Q factors
Quality
Radiation
Radiation exposure
Radiation protection
Relative Biological Effectiveness
Relative biological effectiveness (RBE)
Risk factors
Transformation
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Summary:The biological effects of high charge and energy (HZE) particle exposures are of interest in space radiation protection of astronauts and cosmonauts, and estimating secondary cancer risks for patients undergoing Hadron therapy for primary cancers. The large number of particles types and energies that makeup primary or secondary radiation in HZE particle exposures precludes tumor induction studies in animal models for all but a few particle types and energies, thus leading to the use of surrogate endpoints to investigate the details of the radiation quality dependence of relative biological effectiveness (RBE) factors. In this report we make detailed RBE predictions of the charge number and energy dependence of RBE's using a parametric track structure model to represent experimental results for the low dose response for chromosomal exchanges in normal human lymphocyte and fibroblast cells with comparison to published data for neoplastic transformation and gene mutation. RBE's are evaluated against acute doses of γ-rays for doses near 1 Gy. Models that assume linear or non-targeted effects at low dose are considered. Modest values of RBE (10) are predicted at low doses
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0153998