High Proportion of HIV-HCV Coinfected Patients with Advanced Liver Fibrosis Requiring Hepatitis C Treatment in Haiphong, Northern Vietnam (ANRS 12262)

• Published in: PloS one 2016-05, Vol.11 (5), p.e0153744-e0153744
• Main Authors: Nguyen Truong, Tam, Laureillard, Didier, Lacombe, Karine, Duong Thi, Huong, Pham Thi Hanh, Phuc, Truong Thi Xuan, Lien, Chu Thi, Nga, Luong Que, Anh, Vu Hai, Vinh, Nagot, Nicolas, Tuaillon, Edouard, Dominguez, Stéphanie, Lemoine, Maud
• Format: Article
• Language: English
• Subjects: Abuse; Acquired immune deficiency syndrome; Adult; Adults; AIDS; Alcohol; Alcohol abuse; Alcohol use; Alcoholic beverages; Anti-HIV Agents - therapeutic use; Antiretroviral agents; Antiretroviral therapy; Antiviral Agents - therapeutic use; Biology and life sciences; Care and treatment; CD4 antigen; Cirrhosis; Coinfection - drug therapy; Coinfection - epidemiology; Coinfection - virology; Complications and side effects; Cross-Sectional Studies; Disease control; Drug abuse; Drug therapy; Drugs; Epidemiology; Female; Fibrosis; Genotypes; Health aspects; Health care access; Health risks; Hepatitis; Hepatitis C; Hepatitis C - complications; Hepatitis C - drug therapy; Hepatitis C - epidemiology; Hepatitis C - virology; Hepatitis C virus; Hepatology; HIV; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - virology; Hospitals; Human health and pathology; Human immunodeficiency virus; Humans; Infections; Infectious diseases; Life Sciences; Liver; Liver cirrhosis; Liver Cirrhosis - epidemiology; Liver Cirrhosis - etiology; Liver Cirrhosis - virology; Liver diseases; Liver failure; Lopinavir; Male; Males; Medicine and health sciences; Multivariate analysis; Narcotics; Nevirapine; Pathogenesis; Patients; People and Places; Population; Public health; Ribonucleic acid; Risk analysis; Risk factors; RNA; Serology; Severity of Illness Index; Substance abuse treatment; Surveys and Questionnaires; Tropical diseases; Vietnam - epidemiology; Virology
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0153744

Screening and treatment for chronic hepatitis C are very limited in Vietnam and clinical data on HCV-related liver disease in HIV-coinfected people are almost inexistent. This study aimed to assess the severity of liver fibrosis and its risk factors in HIV-HCV coinfected patients in Haiphong, Northern Vietnam. A cross-sectional study was conducted at a HIV outpatient clinic. Consecutive HIV treated adults with positive HCV serology completed a standardised epidemiological questionnaire and had a comprehensive liver assessment including hepatic elastography (Fibroscan®, Echosens). From February to March 2014, 104 HIV-HCV coinfected patients receiving antiretroviral therapy (ART) were prospectively enrolled (99 males, median age: 35.8 (32.7-39.6) years, median CD4 count: 504 (361-624) /mm3. Of them, 93 (89.4%) had detectable HCV RNA (median 6.19 (4.95-6.83 Log10 IU/mL). Patients were mainly infected with genotypes 1a/1b (69%) and genotypes 6a/6e (26%). Forty-three patients (41.3%) had fibrosis ≥F2 including 24 patients (23.1%) with extensive fibrosis (F3) and/or cirrhosis (F4). In univariate analysis, excessive alcohol consumption, estimated time duration from HCV infection, nevirapine and lopinavir-based ARV regimen and CD4 nadir were associated factors of extensive fibrosis/cirrhosis. Alcohol abuse was the only independent factor of extensive fibrosis in multivariate analysis. Using Fibroscan® as a gold standard, the high thresholds of AST-to-platelet ratio index (APRI) and fibrosis-4 score (FIB-4) had very good performances for the diagnosis of extensive fibrosis/cirrhosis (Se: 90 and 100%, Sp:84 and 81%, AUROCs = 0.93, 95%CI: 0.86-0.99 and 0.96 (0.92-0.99), respectively). In this study, nearly 25% of HIV-HCV coinfected patients successfully treated with ART have extensive fibrosis or cirrhosis, and therefore require urgently HCV treatment.