Genome Sequence of Canine Herpesvirus

Canine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154) isolated in the United Kingdom between 1985 and 2000. The sequences a...

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Bibliographic Details
Published in:PloS one 2016-05, Vol.11 (5), p.e0156015-e0156015
Main Authors: Papageorgiou, Konstantinos V, Suárez, Nicolás M, Wilkie, Gavin S, McDonald, Michael, Graham, Elizabeth M, Davison, Andrew J
Format: Article
Language:English
Subjects:
Alphaherpesvirinae - genetics
Alphaherpesvirus
Amino Acid Sequence
Animals
Base Sequence
Bioinformatics
Biology and Life Sciences
Canine herpesvirus
Cetacea
Chromosome Mapping
Deoxyribonucleic acid
Disease
DNA
Dog Diseases - virology
Dogs
Gene sequencing
Genes, Viral
Genetic aspects
Genome, Viral
Genomes
Hemorrhagic disease
Hemorrhagic Disorders - veterinary
Hemorrhagic Disorders - virology
Herpes viruses
Herpesviruses
Infections
Madin Darby Canine Kidney Cells
Medical treatment
Neonates
Nucleotide sequence
Open Reading Frames
Pathology
Physiological aspects
Proteins
Public health
Research and Analysis Methods
Sequence Analysis, DNA
Veterinary medicine
Viral genetics
Viral Proteins - genetics
Viruses
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Summary:Canine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154) isolated in the United Kingdom between 1985 and 2000. The sequences are very closely related to each other. The canine herpesvirus genome is estimated to be 125 kbp in size and consists of a unique long sequence (97.5 kbp) and a unique short sequence (7.7 kbp) that are each flanked by terminal and internal inverted repeats (38 bp and 10.0 kbp, respectively). The overall nucleotide composition is 31.6% G+C, which is the lowest among the completely sequenced alphaherpesviruses. The genome contains 76 open reading frames predicted to encode functional proteins, all of which have counterparts in other alphaherpesviruses. The availability of the sequences will facilitate future research on the diagnosis and treatment of canine herpesvirus-associated disease.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0156015