Lysosomal Acid Lipase Activity Is Reduced Both in Cryptogenic Cirrhosis and in Cirrhosis of Known Etiology

Liver cirrhosis is characterized by a severe acquired reduction of LAL-activity, the precise causes and consequences of which need to be further addressed. DBS-determined lysosomal enzyme activities seem to be affected by white blood cell and platelet counts, and the specificity of these tests can b...

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Bibliographic Details
Published in:PloS one 2016-05, Vol.11 (5), p.e0156113-e0156113
Main Authors: Vespasiani-Gentilucci, Umberto, Gallo, Paolo, Piemonte, Fiorella, Riva, Elisabetta, Porcari, Aldostefano, Vorini, Ferruccio, Tozzi, Giulia, Piccioni, Livia, Galati, Giovanni, De Vincentis, Antonio, Carotti, Simone, Morini, Sergio, D'Amico, Jessica, Angeletti, Silvia, Pedone, Claudio, Picardi, Antonio
Format: Article
Language:English
Subjects:
Acids
Aged
Biology and Life Sciences
Blood
Cholesterol
Cirrhosis
College campuses
Development and progression
Down-Regulation
Dried Blood Spot Testing
Enzymes
Etiology
Etiology (Medicine)
Female
Gene polymorphism
Genetic aspects
Genetic Predisposition to Disease
Hepatology
High-Throughput Nucleotide Sequencing
Hospitals
Humans
Immunoglobulins
Internal medicine
Laboratories
Leukocyte Count
Leukocytes
LipA protein
Lipase
Liver
Liver cirrhosis
Liver Cirrhosis - congenital
Liver Cirrhosis - enzymology
Liver Cirrhosis - etiology
Liver Cirrhosis - genetics
Liver diseases
Male
Medicine
Medicine and Health Sciences
Metabolism
Middle Aged
Multivariate analysis
Mutation
Patients
Physiological aspects
Platelet Count
Platelets
Polymorphism
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Single-nucleotide polymorphism
Steatosis
Sterol Esterase - genetics
Sterol Esterase - metabolism
Triglycerides
Virology
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Description
Summary:Liver cirrhosis is characterized by a severe acquired reduction of LAL-activity, the precise causes and consequences of which need to be further addressed. DBS-determined lysosomal enzyme activities seem to be affected by white blood cell and platelet counts, and the specificity of these tests can be reduced when applied to determined populations, such as cirrhotics.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0156113