Loading…
Pd@Ag Nanosheets in Combination with Amphotericin B Exert a Potent Anti-Cryptococcal Fungicidal Effect
Silver nanoparticles have received considerable interest as new "nanoantibiotics" with the potential to kill drug-resistant microorganisms. Recently, a class of new core-shell nanostructures, Pd@Ag nanosheets (Pd@Ag NSs), were created using deposition techniques and demonstrated excellent...
Saved in:
| Published in: | PloS one 2016-06, Vol.11 (6), p.e0157000 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c692t-b87a96c5e02b5cec5b885862ecc1de5bc8746ee4b6d28c4f700bee45691b38513 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c692t-b87a96c5e02b5cec5b885862ecc1de5bc8746ee4b6d28c4f700bee45691b38513 |
| container_end_page | |
| container_issue | 6 |
| container_start_page | e0157000 |
| container_title | PloS one |
| container_volume | 11 |
| creator | Zhang, Chao Chen, Mei Wang, Guizhen Fang, Wei Ye, Chen Hu, Hanhua Fa, Zhenzong Yi, Jiu Liao, Wan-Qing |
| description | Silver nanoparticles have received considerable interest as new "nanoantibiotics" with the potential to kill drug-resistant microorganisms. Recently, a class of new core-shell nanostructures, Pd@Ag nanosheets (Pd@Ag NSs), were created using deposition techniques and demonstrated excellent inhibitory effects on various bacteria in vitro. In this study, we evaluated the antifungal activity of Pd@Ag NSs against common invasive fungal pathogens. Among these organisms, Cryptococcus neoformans complex species was most susceptible to Pd@Ag NSs, which exhibited potent antifungal activity against various molecular types or sources of cryptococcal strains including fluconazole-resistant isolates. The anticryptococcal activity of Pd@Ag NSs was significantly greater than fluconazole and similar to that of amphotericin B (AmB). At relatively high concentrations, Pd@Ag NSs exhibited fungicidal activity against Cryptococcus spp., which can likely be attributed to the disruption of cell integrity, intracellular protein synthesis, and energy metabolism. Intriguingly, Pd@Ag NSs also exhibited strong synergistic anti-cryptococcal fungicidal effects at low concentrations in combination with AmB but exhibited much better safety in erythrocytes than AmB, even at the minimal fungicidal concentration. Therefore, Pd@Ag NSs may be a promising adjunctive agent for treating cryptococcosis, and further investigation for clinical applications is required. |
| doi_str_mv | 10.1371/journal.pone.0157000 |
| format | article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1794512536</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A454437410</galeid><doaj_id>oai_doaj_org_article_318010625b614bbaaa93e2e72d51efc4</doaj_id><sourcerecordid>A454437410</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-b87a96c5e02b5cec5b885862ecc1de5bc8746ee4b6d28c4f700bee45691b38513</originalsourceid><addsrcrecordid>eNqNkl-L1DAUxYso7rr6DUQLguDDjEmapO3L4jjM6sDiLv57DUl622boNGOS6u63N-N0lykoSB6a3Pzu6c3hJMlzjOY4y_HbjR1cL7v5zvYwR5jlCKEHySkuMzLjBGUPj_YnyRPvNwixrOD8cXJCcpJHEX6a1NfVu0WTfpK99S1A8Knp06XdKtPLYGyf_jKhTRfbXWsDOKPj7ft0dQMupDK9jrU-pIs-mNnS3e6C1VZr2aUXQ99EtorbVV2DDk-TR7XsPDwbv2fJt4vV1-XH2eXVh_VycTnTvCRhpopcllwzQEQxDZqpomAFJ6A1roApXeSUA1DFK1JoWsc3q3hkvMQqKxjOzpKXB91dZ70YLfIC5yVlmLCMR2J9ICorN2LnzFa6W2GlEX8K1jVCumB0ByLDBcKIE6Y4pkpJKcsMCOSkYhhqTaPW-fi3QW2h0tEMJ7uJ6PSmN61o7E9Bi5JTsh_31Sjg7I8BfPjHyCPVyDiV6WsbxfTWeC0WlFGa5RSjSM3_QsVVwdboGJLaxPqk4c2kITIBbkIjB-_F-svn_2evvk_Z10dsC7ILrbfdsI-Tn4L0AGpnvXdQ3zuHkdhn_M4Nsc-4GDMe214cu37fdBfq7Dfu5_aV</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1794512536</pqid></control><display><type>article</type><title>Pd@Ag Nanosheets in Combination with Amphotericin B Exert a Potent Anti-Cryptococcal Fungicidal Effect</title><source>Open Access: PubMed Central</source><source>ProQuest - Publicly Available Content Database</source><creator>Zhang, Chao ; Chen, Mei ; Wang, Guizhen ; Fang, Wei ; Ye, Chen ; Hu, Hanhua ; Fa, Zhenzong ; Yi, Jiu ; Liao, Wan-Qing</creator><contributor>Nielsen, Kirsten</contributor><creatorcontrib>Zhang, Chao ; Chen, Mei ; Wang, Guizhen ; Fang, Wei ; Ye, Chen ; Hu, Hanhua ; Fa, Zhenzong ; Yi, Jiu ; Liao, Wan-Qing ; Nielsen, Kirsten</creatorcontrib><description>Silver nanoparticles have received considerable interest as new "nanoantibiotics" with the potential to kill drug-resistant microorganisms. Recently, a class of new core-shell nanostructures, Pd@Ag nanosheets (Pd@Ag NSs), were created using deposition techniques and demonstrated excellent inhibitory effects on various bacteria in vitro. In this study, we evaluated the antifungal activity of Pd@Ag NSs against common invasive fungal pathogens. Among these organisms, Cryptococcus neoformans complex species was most susceptible to Pd@Ag NSs, which exhibited potent antifungal activity against various molecular types or sources of cryptococcal strains including fluconazole-resistant isolates. The anticryptococcal activity of Pd@Ag NSs was significantly greater than fluconazole and similar to that of amphotericin B (AmB). At relatively high concentrations, Pd@Ag NSs exhibited fungicidal activity against Cryptococcus spp., which can likely be attributed to the disruption of cell integrity, intracellular protein synthesis, and energy metabolism. Intriguingly, Pd@Ag NSs also exhibited strong synergistic anti-cryptococcal fungicidal effects at low concentrations in combination with AmB but exhibited much better safety in erythrocytes than AmB, even at the minimal fungicidal concentration. Therefore, Pd@Ag NSs may be a promising adjunctive agent for treating cryptococcosis, and further investigation for clinical applications is required.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0157000</identifier><identifier>PMID: 27271376</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amphotericin B ; Amphotericin B - pharmacology ; Antifungal activity ; Antifungal agents ; Antifungal Agents - pharmacology ; Antimicrobial agents ; Bacteria ; Biology and Life Sciences ; Candida ; Chemistry ; Complications and side effects ; Core-shell structure ; Cryptococcosis ; Cryptococcus ; Cryptococcus neoformans ; Cryptococcus neoformans - drug effects ; Dermatology ; Dosage and administration ; Dose-Response Relationship, Drug ; Drug resistance ; Drug Synergism ; Energy metabolism ; Engineering and Technology ; Erythrocytes ; Fluconazole ; Fungal infections ; Fungi ; Fungicidal activity ; Fungicides ; Laboratories ; Low concentrations ; Medicine and Health Sciences ; Meningitis ; Metabolism ; Microbial Sensitivity Tests ; Microorganisms ; Molecular chains ; Nanomaterials ; Nanoparticles ; Nanosheets ; Nanostructure ; Nanostructures - chemistry ; Nanotechnology ; Palladium ; Physiological aspects ; Properties ; Protein biosynthesis ; Protein synthesis ; Protein turnover ; Proteins ; Saccharomyces cerevisiae ; Silver ; Silver - pharmacology ; Therapeutic applications ; Toxicity</subject><ispartof>PloS one, 2016-06, Vol.11 (6), p.e0157000</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Zhang et al 2016 Zhang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b87a96c5e02b5cec5b885862ecc1de5bc8746ee4b6d28c4f700bee45691b38513</citedby><cites>FETCH-LOGICAL-c692t-b87a96c5e02b5cec5b885862ecc1de5bc8746ee4b6d28c4f700bee45691b38513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1794512536/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1794512536?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27271376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Nielsen, Kirsten</contributor><creatorcontrib>Zhang, Chao</creatorcontrib><creatorcontrib>Chen, Mei</creatorcontrib><creatorcontrib>Wang, Guizhen</creatorcontrib><creatorcontrib>Fang, Wei</creatorcontrib><creatorcontrib>Ye, Chen</creatorcontrib><creatorcontrib>Hu, Hanhua</creatorcontrib><creatorcontrib>Fa, Zhenzong</creatorcontrib><creatorcontrib>Yi, Jiu</creatorcontrib><creatorcontrib>Liao, Wan-Qing</creatorcontrib><title>Pd@Ag Nanosheets in Combination with Amphotericin B Exert a Potent Anti-Cryptococcal Fungicidal Effect</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Silver nanoparticles have received considerable interest as new "nanoantibiotics" with the potential to kill drug-resistant microorganisms. Recently, a class of new core-shell nanostructures, Pd@Ag nanosheets (Pd@Ag NSs), were created using deposition techniques and demonstrated excellent inhibitory effects on various bacteria in vitro. In this study, we evaluated the antifungal activity of Pd@Ag NSs against common invasive fungal pathogens. Among these organisms, Cryptococcus neoformans complex species was most susceptible to Pd@Ag NSs, which exhibited potent antifungal activity against various molecular types or sources of cryptococcal strains including fluconazole-resistant isolates. The anticryptococcal activity of Pd@Ag NSs was significantly greater than fluconazole and similar to that of amphotericin B (AmB). At relatively high concentrations, Pd@Ag NSs exhibited fungicidal activity against Cryptococcus spp., which can likely be attributed to the disruption of cell integrity, intracellular protein synthesis, and energy metabolism. Intriguingly, Pd@Ag NSs also exhibited strong synergistic anti-cryptococcal fungicidal effects at low concentrations in combination with AmB but exhibited much better safety in erythrocytes than AmB, even at the minimal fungicidal concentration. Therefore, Pd@Ag NSs may be a promising adjunctive agent for treating cryptococcosis, and further investigation for clinical applications is required.</description><subject>Amphotericin B</subject><subject>Amphotericin B - pharmacology</subject><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Biology and Life Sciences</subject><subject>Candida</subject><subject>Chemistry</subject><subject>Complications and side effects</subject><subject>Core-shell structure</subject><subject>Cryptococcosis</subject><subject>Cryptococcus</subject><subject>Cryptococcus neoformans</subject><subject>Cryptococcus neoformans - drug effects</subject><subject>Dermatology</subject><subject>Dosage and administration</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug resistance</subject><subject>Drug Synergism</subject><subject>Energy metabolism</subject><subject>Engineering and Technology</subject><subject>Erythrocytes</subject><subject>Fluconazole</subject><subject>Fungal infections</subject><subject>Fungi</subject><subject>Fungicidal activity</subject><subject>Fungicides</subject><subject>Laboratories</subject><subject>Low concentrations</subject><subject>Medicine and Health Sciences</subject><subject>Meningitis</subject><subject>Metabolism</subject><subject>Microbial Sensitivity Tests</subject><subject>Microorganisms</subject><subject>Molecular chains</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanosheets</subject><subject>Nanostructure</subject><subject>Nanostructures - chemistry</subject><subject>Nanotechnology</subject><subject>Palladium</subject><subject>Physiological aspects</subject><subject>Properties</subject><subject>Protein biosynthesis</subject><subject>Protein synthesis</subject><subject>Protein turnover</subject><subject>Proteins</subject><subject>Saccharomyces cerevisiae</subject><subject>Silver</subject><subject>Silver - pharmacology</subject><subject>Therapeutic applications</subject><subject>Toxicity</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl-L1DAUxYso7rr6DUQLguDDjEmapO3L4jjM6sDiLv57DUl622boNGOS6u63N-N0lykoSB6a3Pzu6c3hJMlzjOY4y_HbjR1cL7v5zvYwR5jlCKEHySkuMzLjBGUPj_YnyRPvNwixrOD8cXJCcpJHEX6a1NfVu0WTfpK99S1A8Knp06XdKtPLYGyf_jKhTRfbXWsDOKPj7ft0dQMupDK9jrU-pIs-mNnS3e6C1VZr2aUXQ99EtorbVV2DDk-TR7XsPDwbv2fJt4vV1-XH2eXVh_VycTnTvCRhpopcllwzQEQxDZqpomAFJ6A1roApXeSUA1DFK1JoWsc3q3hkvMQqKxjOzpKXB91dZ70YLfIC5yVlmLCMR2J9ICorN2LnzFa6W2GlEX8K1jVCumB0ByLDBcKIE6Y4pkpJKcsMCOSkYhhqTaPW-fi3QW2h0tEMJ7uJ6PSmN61o7E9Bi5JTsh_31Sjg7I8BfPjHyCPVyDiV6WsbxfTWeC0WlFGa5RSjSM3_QsVVwdboGJLaxPqk4c2kITIBbkIjB-_F-svn_2evvk_Z10dsC7ILrbfdsI-Tn4L0AGpnvXdQ3zuHkdhn_M4Nsc-4GDMe214cu37fdBfq7Dfu5_aV</recordid><startdate>20160607</startdate><enddate>20160607</enddate><creator>Zhang, Chao</creator><creator>Chen, Mei</creator><creator>Wang, Guizhen</creator><creator>Fang, Wei</creator><creator>Ye, Chen</creator><creator>Hu, Hanhua</creator><creator>Fa, Zhenzong</creator><creator>Yi, Jiu</creator><creator>Liao, Wan-Qing</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160607</creationdate><title>Pd@Ag Nanosheets in Combination with Amphotericin B Exert a Potent Anti-Cryptococcal Fungicidal Effect</title><author>Zhang, Chao ; Chen, Mei ; Wang, Guizhen ; Fang, Wei ; Ye, Chen ; Hu, Hanhua ; Fa, Zhenzong ; Yi, Jiu ; Liao, Wan-Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-b87a96c5e02b5cec5b885862ecc1de5bc8746ee4b6d28c4f700bee45691b38513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Amphotericin B</topic><topic>Amphotericin B - pharmacology</topic><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - pharmacology</topic><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Biology and Life Sciences</topic><topic>Candida</topic><topic>Chemistry</topic><topic>Complications and side effects</topic><topic>Core-shell structure</topic><topic>Cryptococcosis</topic><topic>Cryptococcus</topic><topic>Cryptococcus neoformans</topic><topic>Cryptococcus neoformans - drug effects</topic><topic>Dermatology</topic><topic>Dosage and administration</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug resistance</topic><topic>Drug Synergism</topic><topic>Energy metabolism</topic><topic>Engineering and Technology</topic><topic>Erythrocytes</topic><topic>Fluconazole</topic><topic>Fungal infections</topic><topic>Fungi</topic><topic>Fungicidal activity</topic><topic>Fungicides</topic><topic>Laboratories</topic><topic>Low concentrations</topic><topic>Medicine and Health Sciences</topic><topic>Meningitis</topic><topic>Metabolism</topic><topic>Microbial Sensitivity Tests</topic><topic>Microorganisms</topic><topic>Molecular chains</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Nanosheets</topic><topic>Nanostructure</topic><topic>Nanostructures - chemistry</topic><topic>Nanotechnology</topic><topic>Palladium</topic><topic>Physiological aspects</topic><topic>Properties</topic><topic>Protein biosynthesis</topic><topic>Protein synthesis</topic><topic>Protein turnover</topic><topic>Proteins</topic><topic>Saccharomyces cerevisiae</topic><topic>Silver</topic><topic>Silver - pharmacology</topic><topic>Therapeutic applications</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Chao</creatorcontrib><creatorcontrib>Chen, Mei</creatorcontrib><creatorcontrib>Wang, Guizhen</creatorcontrib><creatorcontrib>Fang, Wei</creatorcontrib><creatorcontrib>Ye, Chen</creatorcontrib><creatorcontrib>Hu, Hanhua</creatorcontrib><creatorcontrib>Fa, Zhenzong</creatorcontrib><creatorcontrib>Yi, Jiu</creatorcontrib><creatorcontrib>Liao, Wan-Qing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Chao</au><au>Chen, Mei</au><au>Wang, Guizhen</au><au>Fang, Wei</au><au>Ye, Chen</au><au>Hu, Hanhua</au><au>Fa, Zhenzong</au><au>Yi, Jiu</au><au>Liao, Wan-Qing</au><au>Nielsen, Kirsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pd@Ag Nanosheets in Combination with Amphotericin B Exert a Potent Anti-Cryptococcal Fungicidal Effect</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-06-07</date><risdate>2016</risdate><volume>11</volume><issue>6</issue><spage>e0157000</spage><pages>e0157000-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Silver nanoparticles have received considerable interest as new "nanoantibiotics" with the potential to kill drug-resistant microorganisms. Recently, a class of new core-shell nanostructures, Pd@Ag nanosheets (Pd@Ag NSs), were created using deposition techniques and demonstrated excellent inhibitory effects on various bacteria in vitro. In this study, we evaluated the antifungal activity of Pd@Ag NSs against common invasive fungal pathogens. Among these organisms, Cryptococcus neoformans complex species was most susceptible to Pd@Ag NSs, which exhibited potent antifungal activity against various molecular types or sources of cryptococcal strains including fluconazole-resistant isolates. The anticryptococcal activity of Pd@Ag NSs was significantly greater than fluconazole and similar to that of amphotericin B (AmB). At relatively high concentrations, Pd@Ag NSs exhibited fungicidal activity against Cryptococcus spp., which can likely be attributed to the disruption of cell integrity, intracellular protein synthesis, and energy metabolism. Intriguingly, Pd@Ag NSs also exhibited strong synergistic anti-cryptococcal fungicidal effects at low concentrations in combination with AmB but exhibited much better safety in erythrocytes than AmB, even at the minimal fungicidal concentration. Therefore, Pd@Ag NSs may be a promising adjunctive agent for treating cryptococcosis, and further investigation for clinical applications is required.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27271376</pmid><doi>10.1371/journal.pone.0157000</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-06, Vol.11 (6), p.e0157000 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1794512536 |
| source | Open Access: PubMed Central; ProQuest - Publicly Available Content Database |
| subjects | Amphotericin B Amphotericin B - pharmacology Antifungal activity Antifungal agents Antifungal Agents - pharmacology Antimicrobial agents Bacteria Biology and Life Sciences Candida Chemistry Complications and side effects Core-shell structure Cryptococcosis Cryptococcus Cryptococcus neoformans Cryptococcus neoformans - drug effects Dermatology Dosage and administration Dose-Response Relationship, Drug Drug resistance Drug Synergism Energy metabolism Engineering and Technology Erythrocytes Fluconazole Fungal infections Fungi Fungicidal activity Fungicides Laboratories Low concentrations Medicine and Health Sciences Meningitis Metabolism Microbial Sensitivity Tests Microorganisms Molecular chains Nanomaterials Nanoparticles Nanosheets Nanostructure Nanostructures - chemistry Nanotechnology Palladium Physiological aspects Properties Protein biosynthesis Protein synthesis Protein turnover Proteins Saccharomyces cerevisiae Silver Silver - pharmacology Therapeutic applications Toxicity |
| title | Pd@Ag Nanosheets in Combination with Amphotericin B Exert a Potent Anti-Cryptococcal Fungicidal Effect |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T07%3A17%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pd@Ag%20Nanosheets%20in%20Combination%20with%20Amphotericin%20B%20Exert%20a%20Potent%20Anti-Cryptococcal%20Fungicidal%20Effect&rft.jtitle=PloS%20one&rft.au=Zhang,%20Chao&rft.date=2016-06-07&rft.volume=11&rft.issue=6&rft.spage=e0157000&rft.pages=e0157000-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0157000&rft_dat=%3Cgale_plos_%3EA454437410%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c692t-b87a96c5e02b5cec5b885862ecc1de5bc8746ee4b6d28c4f700bee45691b38513%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1794512536&rft_id=info:pmid/27271376&rft_galeid=A454437410&rfr_iscdi=true |