Transcriptome Analysis and Gene Identification in the Pulmonary Artery of Broilers with Ascites Syndrome

Pulmonary arterial hypertension, also known as Ascites syndrome (AS), remains a clinically challenging disease with a large impact on both humans and broiler chickens. Pulmonary arterial remodeling presents a key step in the development of AS. The precise molecular mechanism of pulmonary artery remo...

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Bibliographic Details
Published in:PloS one 2016-06, Vol.11 (6), p.e0156045-e0156045
Main Authors: Yang, Fei, Cao, Huabin, Xiao, Qingyang, Guo, Xiaoquan, Zhuang, Yu, Zhang, Caiying, Wang, Tiancheng, Lin, Huayuan, Song, Yalu, Hu, Guoliang, Liu, Ping
Format: Article
Language:English
Subjects:
Animal populations
Animal sciences
Animals
Arteries
Ascites
Avian Proteins - biosynthesis
Biology and Life Sciences
Bone morphogenetic proteins
Care and treatment
Cell proliferation
Chickens
Chickens - metabolism
Circuits
Cytokines
Development and progression
Encyclopedias
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Gene sequencing
Genes
Genomes
Heart
Humans
Hypertension
Hypertension, Pulmonary - metabolism
Hypertension, Pulmonary - physiopathology
Hypoxia
Interleukin 18
Interleukin 6
Interleukin 8
Kinases
Lungs
Medicine and Health Sciences
Metabolism
Molecular chains
Pathogenesis
Pathways
Physiological aspects
Poultry
Poultry Diseases - metabolism
Poultry Diseases - physiopathology
Pulmonary arteries
Pulmonary artery
Pulmonary Artery - metabolism
Pulmonary Artery - physiopathology
Pulmonary hypertension
Regulators
Research and analysis methods
Ribonucleic acid
RNA
RNA sequencing
Smooth muscle
Stat3 protein
Stat5 protein
Tumor necrosis factor-TNF
Vascular Remodeling
Veins & arteries
Zoology
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Summary:Pulmonary arterial hypertension, also known as Ascites syndrome (AS), remains a clinically challenging disease with a large impact on both humans and broiler chickens. Pulmonary arterial remodeling presents a key step in the development of AS. The precise molecular mechanism of pulmonary artery remodeling regulating AS progression remains unclear. We obtained pulmonary arteries from two positive AS and two normal broilers for RNA sequencing (RNA-seq) analysis and pathological observation. RNA-seq analysis revealed a total of 895 significantly differentially expressed genes (DEGs) with 437 up-regulated and 458 down-regulated genes, which were significantly enriched to 12 GO (Gene Ontology) terms and 4 KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways (Padj
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0156045