Fecal Microbiota Transplantation for Ulcerative Colitis: A Systematic Review and Meta-Analysis

• Published in: PloS one 2016-06, Vol.11 (6), p.e0157259-e0157259
• Main Authors: Shi, Yanqiang, Dong, Yiwei, Huang, Wenhui, Zhu, Decong, Mao, Hua, Su, Peizhu
• Format: Article
• Language: English
• Subjects: Analysis; Bacteria; Biology and Life Sciences; Care and treatment; Case studies; Clinical trials; Cohort analysis; Colitis, Ulcerative - microbiology; Colitis, Ulcerative - therapy; Colon; Complications and side effects; Composition effects; Confidence intervals; Faecalibacterium; Fecal Microbiota Transplantation - adverse effects; Fecal Microbiota Transplantation - methods; Fecal microflora; Feces - microbiology; Gastrointestinal Microbiome; Humans; Inflammatory bowel disease; Intestinal microflora; Lactobacillus; Medicine and Health Sciences; Meta-analysis; Microbiota; Microbiota (Symbiotic organisms); Patients; Physical Sciences; Remission; Remission Induction; Research and Analysis Methods; Safety; Similarity; Studies; Systematic review; Transplantation; Treatment Outcome; Ulcerative colitis
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0157259

Fecal microbiota transplantation (FMT) has been recognized as a novel treatment for ulcerative colitis (UC). However, its efficacy and safety remain unclear. We conducted this systematic review to assess the efficacy and safety of FMT in UC. PubMed, EMBASE, Cochrane Central, Web of Science Core Collection, and three other Chinese databases were searched for reports of FMT in UC with clear outcomes. We estimated pooled rates [with 95% confidence interval (CI)] of clinical remission among 15 cohort studies and clinical response among 16 cohort studies. Twenty five studies (2 randomized controlled trials, 15 cohort studies, and 8 case studies) with 234 UC patients were included. Overall, 41.58% (84/202) patients achieved clinical remission (CR) and 65.28% (126/193) achieved clinical response. Among the cohort studies, the pooled estimate of patients who achieved CR and clinical response were 40.5% (95% CI 24.7%-58.7%), and 66.1% (95% CI 43.7%-83.0%). Most adverse events were slight and self-resolving. The analyses of gut microbiota in 7 studies showed that FMT could increase microbiota diversity and richness, similarity, and certain change of bacterial composition. FMT provides a promising effect for UC with few adverse events. Successful FMT may be associated with an increase in microbiota diversity and richness, similarity, and certain change of bacterial composition.