Potential Role of Vegetarianism on Nutritional and Cardiovascular Status in Taiwanese Dialysis Patients: A Case-Control Study

• Published in: PloS one 2016-06, Vol.11 (6), p.e0156297-e0156297
• Main Authors: Ou, Shih-Hsiang, Chen, Mei-Yin, Huang, Chien-Wei, Chen, Nai-Ching, Wu, Chien-Hsing, Hsu, Chih-Yang, Chou, Kang-Ju, Lee, Po-Tsang, Fang, Hua-Chang, Chen, Chien-Liang
• Format: Article
• Language: English
• Subjects: Adult; Aged; Analysis; Ankle Brachial Index; Biochemistry; Biology and Life Sciences; Blood pressure; Body Weight - physiology; C-reactive protein; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cardiovascular Physiological Phenomena; Case-Control Studies; Dialysis; Diet; Diet, Vegetarian - statistics & numerical data; Female; Health aspects; Health risk assessment; Humans; Male; Medicine and Health Sciences; Middle Aged; Mortality; Nutritional Status - physiology; Peritoneal dialysis; Physical Sciences; Physiological aspects; Pulse Wave Analysis; Risk Factors; Taiwan - epidemiology; Uric acid; Vascular Stiffness - physiology; Vegetarianism; Vitamin D; Vitamin deficiency; Wave velocity
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0156297

Cardiovascular disease remains the most common cause of death for patients on chronic dialysis. End stage renal disease patients undergoing dialysis imposed to reduce phosphorus intake, which likely contributes to development of vegetarian diet behaviors. Vegetarian diets are often lower in protein content, in contradiction to the recommendation that a high protein diet is followed by patients undergoing dialysis. The purpose of the study was to investigate the effects of a vegetarian diet on the nutritional and cardiovascular status of dialysis patients. A study of 21 vegetarian dialysis patients and 42 age- and sex-matched non-vegetarian dialysis patients selected as controls was conducted in the Kaohsiung Veterans General Hospital. Brachial-ankle pulse wave velocity and biochemistry data including total homocysteine levels, serum lipid profiles, high-sensitivity C-reactive protein, vitamin D levels, albumin, and normalized protein catabolic rate were measured. Compared with the non-vegetarian control group, vegetarian subjects had lower body weight, body mass index, serum phosphate, blood urea nitrogen, serum creatinine, vitamin D, uric acid, albumin, and normalized protein catabolic rate (p < 0.05). The vegetarian group showed higher brachial-ankle pulse wave velocity than the non-vegetarian group (1926.95 ± 456.45 and 1684.82 ± 309.55 cm/sec, respectively, p < 0.05). After adjustment for age, albumin, pre-dialysis systolic blood pressure, and duration of dialysis, vegetarian diet remained an independent risk factor for brachial-ankle pulse wave velocity. The present study revealed that patients on dialysis who follow vegetarian diets may experience subclinical protein malnutrition and vitamin D deficiency that could offset the beneficial cardiovascular effects of vegetarianism.