Low Soluble Syndecan-1 Precedes Preeclampsia

Syndecan-1 (Sdc1; CD138) is a major transmembrane heparan sulfate proteoglycan expressed on the extracellular, luminal surface of epithelial cells and syncytiotrophoblast, thus comprising a major component of the glycocalyx of these cells. The "soluble" (shed) form of Sdc1 has paracrine an...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2016-06, Vol.11 (6), p.e0157608-e0157608
Main Authors: Gandley, Robin E, Althouse, Andrew, Jeyabalan, Arundhathi, Bregand-White, Julia M, McGonigal, Stacy, Myerski, Ashley C, Gallaher, Marcia, Powers, Robert W, Hubel, Carl A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Autocrine signalling
Biology and Life Sciences
Birth Weight
Blood pressure
Case-Control Studies
Control methods
Enzyme-linked immunosorbent assay
Epithelial cells
Female
Gene Expression
Gynecology
Heparan sulfate
Humans
Hypertension
Infant, Newborn
Inflammation
Medicine
Medicine and Health Sciences
mRNA
Obstetrics
Paracrine signalling
Pathogenesis
Placenta
Placenta - metabolism
Placenta - pathology
Plasma
Pre-eclampsia
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Pre-Eclampsia - genetics
Pre-Eclampsia - pathology
Preeclampsia
Pregnancy
Prognosis
Research and Analysis Methods
RNA, Messenger - genetics
Sepsis
Sulfate
Syndecan
Syndecan-1 - analysis
Syndecan-1 - blood
Syndecan-1 - genetics
Trophoblasts - metabolism
Trophoblasts - pathology
Womens health
Wound healing
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Syndecan-1 (Sdc1; CD138) is a major transmembrane heparan sulfate proteoglycan expressed on the extracellular, luminal surface of epithelial cells and syncytiotrophoblast, thus comprising a major component of the glycocalyx of these cells. The "soluble" (shed) form of Sdc1 has paracrine and autocrine functions and is normally produced in a regulated fashion. We compared plasma soluble Sdc1 concentrations, in relation to placental Sdc1 expression, in uncomplicated (control) and preeclamptic pregnancies. We evaluated soluble Sdc1 across uncomplicated pregnancy, and between preeclamptic, gestational hypertensive and control patients at mid-pregnancy (20 weeks) and 3rd trimester by ELISA. Placental expression level of Sdc1 was compared between groups in relation to pre-delivery plasma soluble Sdc1. Participants were recruited from Magee-Womens Hospital. In uncomplicated pregnancy, plasma soluble Sdc1 rose significantly in the 1st trimester, and reached an approximate 50-fold increase at term compared to post pregnancy levels. Soluble Sdc1 was lower at mid-pregnancy in women who later developed preeclampsia (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0157608