Rheumatoid Arthritis Disadvantages Younger Patients for Cardiovascular Diseases: A Meta-Analysis

The incidence of cardiovascular diseases (CVD) is increased in rheumatoid arthritis (RA) patients. It remains unclear whether the load of RA increases cardiovascular (CV) risk especially in female and in younger RA patients. In the present study we aim to analyse the influence of age and gender on C...

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Bibliographic Details
Published in:PloS one 2016-06, Vol.11 (6), p.e0157360-e0157360
Main Authors: Fransen, Jaap, Kazemi-Bajestani, Seyyed M R, Bredie, Sebastian J H, Popa, Calin D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age Factors
Aged
Aged, 80 and over
Arthritis
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - diagnosis
Arthritis, Rheumatoid - epidemiology
Arthritis, Rheumatoid - physiopathology
Biology and Life Sciences
Cardiovascular disease
Cardiovascular diseases
Comparative studies
Coronary artery
Coronary artery disease
Coronary Artery Disease - diagnosis
Coronary Artery Disease - epidemiology
Coronary Artery Disease - etiology
Coronary Artery Disease - physiopathology
Female
Females
Health risk assessment
Health risks
Heart diseases
Humans
Incidence
Male
Males
Medicine and Health Sciences
Meta-analysis
Middle Aged
Mortality
Netherlands - epidemiology
Patients
People and Places
Physical Sciences
Research and Analysis Methods
Rheumatoid arthritis
Risk
Risk Factors
Stroke
Stroke - diagnosis
Stroke - epidemiology
Stroke - etiology
Stroke - physiopathology
Studies
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Summary:The incidence of cardiovascular diseases (CVD) is increased in rheumatoid arthritis (RA) patients. It remains unclear whether the load of RA increases cardiovascular (CV) risk especially in female and in younger RA patients. In the present study we aim to analyse the influence of age and gender on CV risk in RA relative to the general population, using meta-analysis of direct comparative studies. Systematic literature search was performed in MEDLINE for studies reporting on occurrence of CV events in RA as compared to the general population, stratified for gender and/or age. Quality was appraised using the Newcastle-Ottawa scale. Meta-analysis was performed on rate ratios using inverse variance methods. There were 1372 records screened and 13 studies included. RA females and males have a similar higher risk (95%CI) to develop stroke with RR 1.35 (1.30-1.40) and RR 1.31 (1.21-1.43); coronary artery disease with RR 1.65 (1.54-1.76) versus RR 1.55 ((1.41-1.69) in men; cardiovascular disease with RR 1.56 (1.49-1.62) versus 1.50 (1.41-1.60). The highest incidence of CV events was observed in the youngest patients, RR 2.59 (1.77-3.79), whereas older patients had the lowest relative risk when compared to the general population, RR 1.27 (1.16-1.38). The relative risk of RA patients for CVD is age dependent, but does not depend on gender: the relative risk on CVD appears to be equally raised for males and females, while relatively young RA patients (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0157360