MRI Background Parenchymal Enhancement Is Not Associated with Breast Cancer

Previously, a strong positive association between background parenchymal enhancement (BPE) at magnetic resonance imaging (MRI) and breast cancer was reported in high-risk populations. We sought to determine, whether this was also true for non-high-risk patients. 540 consecutive patients underwent br...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2016-07, Vol.11 (7), p.e0158573-e0158573
Main Authors: Bennani-Baiti, Barbara, Dietzel, Matthias, Baltzer, Pascal Andreas
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Analysis
Biology and Life Sciences
Biopsy
Breast - diagnostic imaging
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - diagnostic imaging
Cancer
Correlation
Correlation coefficient
Correlation coefficients
Cross-Sectional Studies
Deoxyribonucleic acid
Diagnosis
DNA
Early Detection of Cancer - methods
Female
Health risks
Humans
Irradiation
Logistic Models
Magnetic resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Mammography
Medical diagnosis
Medicine and Health Sciences
Menstruation
Middle Aged
Multivariate Analysis
Mutation
NMR
Nuclear magnetic resonance
Parenchyma (Botany)
Patients
Radiation
Regression analysis
Research and Analysis Methods
Retrospective Studies
Risk Factors
Risk groups
Ultrasonic imaging
Values
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Previously, a strong positive association between background parenchymal enhancement (BPE) at magnetic resonance imaging (MRI) and breast cancer was reported in high-risk populations. We sought to determine, whether this was also true for non-high-risk patients. 540 consecutive patients underwent breast MRI for assessment of breast findings (BI-RADS 0-5, non-high-risk screening (no familial history of breast cancer, no known genetic mutation, no prior chest irradiation, or previous breast cancer diagnosis)) and subsequent histological work-up. For this IRB-approved study, BPE and fibroglandular tissue FGT were retrospectively assessed by two experienced radiologists according to the BI-RADS lexicon. Pearson correlation coefficients were calculated to explore associations between BPE, FGT, age and final diagnosis of breast cancer. Subsequently, multivariate logistic regression analysis, considering covariate colinearities, was performed, using final diagnosis as the target variable and BPE, FGT and age as covariates. Age showed a moderate negative correlation with FGT (r = -0.43, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0158573