Estrogen and Androgen Hormone Levels Modulate the Expression of PIWI Interacting RNA in Prostate and Breast Cancer

PIWI interacting RNAs (piRNAs), a member of non-coding RNA, originate from intergenic repetitive regions of the genome. piRNA expressions increase in various cancers and it is thought that this increase could be caused by hormones. We aimed to determine the effects of hormones on piRNA expression in...

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Bibliographic Details
Published in:PloS one 2016-07, Vol.11 (7), p.e0159044-e0159044
Main Authors: Oener, Cagri, Cosan, Didem Turgut, Colak, Ertugrul
Format: Article
Language:English
Subjects:
Adhesion
Analysis
Androgens
Androgens - pharmacology
Biology
Biology and Life Sciences
Biotechnology
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Cancer
Cell Adhesion - drug effects
Cell growth
Cell Line, Tumor
Cell proliferation
Cell Proliferation - drug effects
Cell Survival - drug effects
Deoxyribonucleic acid
DNA
DNA methylation
Epigenetics
Estrogens
Estrogens - pharmacology
Female
Gene expression
Gene Expression Regulation, Neoplastic - drug effects
Genomes
Hormones
Humans
Male
Mammals
Medicine and Health Sciences
Non-coding RNA
Physical Sciences
Prostate cancer
Prostatic Neoplasms - genetics
Prostatic Neoplasms - metabolism
Proteins
Ribonucleic acid
RNA
RNA, Small Interfering - genetics
RNA, Small Interfering - metabolism
Stem cells
Tumor cell lines
Tumorigenesis
Viability
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Summary:PIWI interacting RNAs (piRNAs), a member of non-coding RNA, originate from intergenic repetitive regions of the genome. piRNA expressions increase in various cancers and it is thought that this increase could be caused by hormones. We aimed to determine the effects of hormones on piRNA expression in breast and prostate cancer. High viability and a decrease in adhesion were observed at the concentrations of the highest proliferation. Furthermore, an increase in adhesion was also observed in MDA-MB-231 cells. After hormone treatment, while piR-651 expression had increased both breast and prostate cancer cell lines, piR-823 expressions increased in prostate cancer cell lines and only in the breast cancer cell line which was malignant. Thus, it was determined that piR-823 might show different expressions in different type of cancers.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0159044