Radiation Therapy and Cardiac Death in Long-Term Survivors of Esophageal Cancer: An Analysis of the Surveillance, Epidemiology, and End Result Database

Radiation therapy (RT) for esophageal cancer often results in unintended radiation doses delivered to the heart owing to anatomic proximity. Using the Surveillance, Epidemiology, and End Results (SEER) database, we examined late cardiac death in survivors of esophageal cancer that had or had not rec...

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Bibliographic Details
Published in:PloS one 2016-07, Vol.11 (7), p.e0158916-e0158916
Main Authors: Gharzai, Laila, Verma, Vivek, Denniston, Kyle A, Bhirud, Abhijeet R, Bennion, Nathan R, Lin, Chi
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - complications
Adenocarcinoma - epidemiology
Adenocarcinoma - pathology
Adenocarcinoma - radiotherapy
Aged
Analysis
Biology and Life Sciences
Breast cancer
Cancer
Cancer therapies
Carcinoma, Squamous Cell - complications
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - radiotherapy
Cardiac arrest
Cardiovascular disease
Care and treatment
Coronary vessels
Death
Diagnosis
Dosimetry
Epidemiology
Esophageal cancer
Esophageal Neoplasms - complications
Esophageal Neoplasms - epidemiology
Esophageal Neoplasms - pathology
Esophageal Neoplasms - radiotherapy
Esophageal Squamous Cell Carcinoma
Esophagus
Esophagus - pathology
Esophagus - radiation effects
Female
Follow-Up Studies
Health aspects
Health risk assessment
Heart
Heart diseases
Histology
Humans
Identification methods
Incisors
Kaplan-Meier Estimate
Male
Medical diagnosis
Medicine and Health Sciences
Middle Aged
Morbidity
Mortality
Multivariate analysis
Oncology
Patients
Proportional Hazards Models
Radiation
Radiation therapy
Radiotherapy
Risk analysis
Risk factors
Squamous cell carcinoma
Surgery
Surveillance
Survival Analysis
Survivors
Systematic review
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Description
Summary:Radiation therapy (RT) for esophageal cancer often results in unintended radiation doses delivered to the heart owing to anatomic proximity. Using the Surveillance, Epidemiology, and End Results (SEER) database, we examined late cardiac death in survivors of esophageal cancer that had or had not received RT. 5,630 patients were identified that were diagnosed with esophageal squamous cell carcinoma (SCC) or adenocarcinoma (AC) from 1973-2012, who were followed for at least 5 years after therapy. Examined risk factors for cardiac death included age (≤55/56-65/66-75/>75), gender, race (white/non-white), stage (local/regional/distant), histology (SCC/AC), esophageal location (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0158916