Number of Persistent Organic Pollutants Detected at High Concentrations in Blood Samples of the United States Population

• Published in: PloS one 2016-08, Vol.11 (8), p.e0160432-e0160432
• Main Authors: Pumarega, José, Gasull, Magda, Lee, Duk-Hee, López, Tomàs, Porta, Miquel
• Format: Article
• Language: English
• Subjects: Adult; Aged; Air Pollutants - blood; Americans; Analysis; Biology and Life Sciences; Biphenyl; Blood tests; Body mass; Body Mass Index; Body size; Chemical contaminants; Diabetes; Dioxins; Ecology and Environmental Sciences; Economic factors; Ethers; Ethnicity; Female; Halogenated Diphenyl Ethers - blood; Health aspects; Health care; Hispanic Americans; Hispanic people; Hispanics; Hospitals; Humans; Hydrocarbons, Chlorinated - blood; Lipids; Lymphoma; Lymphomas; Male; Medical laboratories; Medical research; Medicine and Health Sciences; Metabolites; Middle Aged; Minority & ethnic groups; Models, Theoretical; Multivariate Analysis; Nutrition; Nutrition Surveys; Odds Ratio; Older people; Organic Chemicals - blood; Organic compounds; Organochlorine compounds; PCB; PCB compounds; People and Places; Persistent organic pollutants; Pesticides; Physical Sciences; Plasma; Pollutants; Polybrominated Biphenyls - blood; Polybrominated diphenyl ethers; Polychlorinated biphenyls; Polychlorinated Biphenyls - blood; Polychlorinated Dibenzodioxins - blood; Population; Poverty; Pregnancy; Preventive medicine; Risk assessment; Social factors; Social Sciences; Socio-economic aspects; Socioeconomic factors; Socioeconomics; Studies; United States
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0160432

Human exposure to environmental chemicals as persistent organic pollutants (POPs) is usually assessed considering each pollutant individually, with little attention to concentrations of mixtures in individuals or social groups. Yet, it may be relatively common for humans to have low and high concentrations of numerous POPs. The study objectives were to analyze the number of POPs detected per person at high concentrations in the U.S. population, and the associations between such type of indicators and socioeconomic factors as gender, race / ethnicity, education, and poverty level. From 91 POPs analyzed in serum samples of 4,739 individuals in three subsamples of the National Health and Nutrition Examination Survey (NHANES) 2003-2004 (the last period with valid updated individual data for the compounds considered in the present study), we computed the number of POPs whose serum concentrations were above selected cutoff points. POPs included were 13 organochlorine compounds (OCs), 10 polybrominated diphenyl ethers (PBDEs), the polybrominated biphenyl (PBB) 153, 38 polychlorinated biphenyls (PCBs), 17 polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs/Fs), and 12 perfluorinated compounds (PFCs). Over 13% of participants had ≥10 of the 37 most detected POPs each at a concentration in the top decile (P90). Over 30% of subjects with total toxic equivalency (TEQ) ≥P75, had ≥10 of 24 POPs not included in TEQ calculations at concentrations ≥P90. Compared to non-Hispanic whites, the adjusted odds ratio of having ≥10 of the 37 POPs at P90 was 9.2 for non-Hispanic blacks and 0.18 for Mexican Americans. Poverty, body mass index, age, and gender were also independently associated with having ≥10 POPs in the top decile. More than one tenth of the US population may have ≥10 POPs each at concentrations in the top decile. Such pattern is nine times more frequent in Non-Hispanic blacks and four times less frequent in Mexican Americans than in non-Hispanic whites.