Impact of Maspin Polymorphism rs2289520 G/C and Its Interaction with Gene to Gene, Alcohol Consumption Increase Susceptibility to Oral Cancer Occurrence

• Published in: PloS one 2016-08, Vol.11 (8), p.e0160841-e0160841
• Main Authors: Yang, Po-Yu, Miao, Nae-Fang, Lin, Chiao-Wen, Chou, Ying-Erh, Yang, Shun-Fa, Huang, Hui-Chuan, Chang, Hsiu-Ju, Tsai, Hsiu-Ting
• Format: Article
• Language: English
• Subjects: Alcohol; Alcohol Drinking - adverse effects; Alcohol use; Alcoholic beverages; Analysis; Apoptosis; Biology; Biology and Life Sciences; Cancer; Case-Control Studies; Cell cycle; Dentistry; Deoxyribonucleic acid; Disease susceptibility; DNA; Drinking (Alcoholic beverages); Environmental risk; Epistasis, Genetic; Extracellular matrix; Female; Gene expression; Gene polymorphism; Genetic polymorphisms; Genetic Predisposition to Disease - genetics; Health aspects; Health risk assessment; Health risks; Heterozygotes; Homozygotes; Hospitals; Humans; Larynx; Male; Medical prognosis; Medical research; Medicine and Health Sciences; Metastasis; Middle Aged; Mouth cancer; Mouth Neoplasms - genetics; Mouth Neoplasms - pathology; Nursing schools; Oral cancer; Patients; Physical Sciences; Polymorphism; Polymorphism, Single Nucleotide; Prostate; Research and Analysis Methods; Risk analysis; Risk factors; Serine; Serine proteinase; Serpins - genetics; Single-nucleotide polymorphism; Tobacco
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0160841

The purpose of this study was to identify gene polymorphisms of mammary serine protease inhibitor (Maspin) specific to patients with oral cancer susceptibility and clinicopathological status. Three single-nucleotide polymorphisms (SNPs) of the Maspin gene from 741 patients with oral cancer and 601 non-cancer controls were analyzed by real-time PCR. The participants with G/G homozygotes or with G/C heterozygotes of Maspin rs2289520 polymorphism had a 2.07-fold (p = 0.01) and a 2.01-fold (p = 0.02) risk of developing oral cancer compared to those with C/C homozygotes. Moreover, gene-gene interaction increased the risk of oral cancer susceptibility among subjects expose to oral cancer related risk factors, including areca, alcohol, and tobacco consumption. G allele of Maspin rs2289520 polymorphism may be a factor that increases the susceptibility to oral cancer. The interactions of gene to oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.