Mastitis Modifies the Biogenic Amines Profile in Human Milk, with Significant Changes in the Presence of Histamine, Putrescine and Spermine

Biogenic amines (BAs) are low molecular weight nitrogenous organic compounds with different biological activities. Putrescine, spermidine and spermine are essential for the development of the gut and immune system of newborns, and are all found in human milk. Little is known, however, about the role...

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Bibliographic Details
Published in:PloS one 2016-09, Vol.11 (9), p.e0162426-e0162426
Main Authors: Perez, Marta, Ladero, Victor, Redruello, Begoña, Del Rio, Beatriz, Fernandez, Leonides, Rodriguez, Juan Miguel, Martín, M Cruz, Fernandez, María, Alvarez, Miguel A
Format: Article
Language:English
Subjects:
Amines
Analysis
Animals
Baby foods
Biogenic amines
Biology and Life Sciences
Breast milk
Breastfeeding & lactation
Cadaverine
Cell division
Cell growth
Composition
Fatty acids
Gene expression
Health aspects
Histamine
Histamine - administration & dosage
Humans
Immune system
Low molecular weights
Mastitis
Medicine and Health Sciences
Metabolism
Milk
Molecular weight
Neonates
Nutritional aspects
Organic compounds
Physical Sciences
Physiology
Polyamines
Putrescine
Putrescine - administration & dosage
Spermidine
Spermine
Tyramine
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Summary:Biogenic amines (BAs) are low molecular weight nitrogenous organic compounds with different biological activities. Putrescine, spermidine and spermine are essential for the development of the gut and immune system of newborns, and are all found in human milk. Little is known, however, about the role of histamine, tyramine or cadaverine in breast milk. Nor is it known whether mastitis alters the BA composition of milk. The BA profile of human milk, and the influence of mastitis on BA concentrations, were therefore investigated. Putrescine, spermidine and spermine were the main BAs detected. In mastitis-affected milk, the concentrations of putrescine, spermine and histamine were higher.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0162426