The Feasibility and Accuracy of Sentinel Lymph Node Biopsy in Initially Clinically Node-Negative Breast Cancer after Neoadjuvant Chemotherapy: A Systematic Review and Meta-Analysis

• Published in: PloS one 2016-09, Vol.11 (9), p.e0162605-e0162605
• Main Authors: Geng, Chong, Chen, Xiao, Pan, Xiaohua, Li, Jiyu
• Format: Article
• Language: English
• Subjects: Adjuvant chemotherapy; Biology and Life Sciences; Biopsy; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cancer; Cancer research; Chemotherapy; Confidence intervals; False Negative Reactions; Feasibility Studies; Female; Humans; Immunohistochemistry; Infrared radiation; Lymph; Lymph node biopsy; Lymph nodes; Lymph Nodes - pathology; Lymphatic Metastasis - pathology; Mastectomy; Medical ethics; Medicine and Health Sciences; Meta-analysis; Neoadjuvant Therapy; Patients; Physical Sciences; Predictive Value of Tests; Publication Bias; Research and Analysis Methods; Sentinel Lymph Node Biopsy; Systematic review
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0162605

With the increased use of neoadjuvant chemotherapy (NAC) in breast cancer, the timing of sentinel lymph node biopsy (SLNB) has become increasingly important. In this study, we aimed to evaluate the feasibility and accuracy of SLNB for initially clinically node-negative breast cancer after NAC by conducting a systematic review and meta-analysis. We searched PubMed, Embase, and the Cochrane Library from January 1, 1993 to November 30, 2015 for studies on initially clinically node-negative breast cancer patients who underwent SLNB after NAC followed by axillary lymph node dissection (ALND). A total of 1,456 patients from 16 studies were included in this review. The pooled identification rate (IR) for SLNB was 96% [95% confidence interval (CI): 95%-97%], and the false negative rate (FNR) was 6% (95% CI: 3%-8%). The pooled sensitivity, negative predictive value (NPV) and accuracy rate (AR) were 94% (95% CI: 92%-97%, I2 = 27.5%), 98% (95% CI: 98%-99%, I2 = 42.7%) and 99% (95% CI: 99%-100%, I2 = 32.6%), respectively. In the subgroup analysis, no significant differences were found in either the IR of an SLNB when different mapping methods were used (P = 0.180) or in the FNR between studies with and without immunohistochemistry (IHC) staining (P = 0.241). Based on current evidence, SLNB is technically feasible and accurate enough for axillary staging in initially clinically node-negative breast cancer patients after NAC.