Altered Markers of Brain Development in Crohn's Disease with Extraintestinal Manifestations - A Pilot Study

Alterations of brain morphology in Crohn's disease have been reported, but data is scarce and heterogenous and the possible impact of disease predisposition on brain development is unknown. Assuming a systemic course of the disease, brain involvement seems more probable in presence of extrainte...

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Bibliographic Details
Published in:PloS one 2016-09, Vol.11 (9), p.e0163202-e0163202
Main Authors: Thomann, Anne K, Thomann, Philipp A, Wolf, Robert C, Hirjak, Dusan, Schmahl, Christian, Ebert, Matthias P, Szabo, Kristina, Reindl, Wolfgang, Griebe, Martin
Format: Article
Language:English
Subjects:
Age
Arthritis
Biology and Life Sciences
Brain
Cholangitis
Cognitive ability
Cortex (cingulate)
Cortex (frontal)
Cortex (insular)
Crohn's disease
Depression (Mood disorder)
Erythema
Erythema nodosum
Fatigue
Fatigue tests
Folding
Frontal lobe
Image resolution
Inflammation
Inflammatory bowel disease
Magnetic resonance
Magnetic resonance imaging
Markers
Medical research
Medicine
Medicine and Health Sciences
Mental depression
Mental health
Microbiota
Neuroimaging
NMR
Nuclear magnetic resonance
Patients
Psychiatry
Psychotherapy
Research and Analysis Methods
Subgroups
Surface area
Systemic diseases
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Summary:Alterations of brain morphology in Crohn's disease have been reported, but data is scarce and heterogenous and the possible impact of disease predisposition on brain development is unknown. Assuming a systemic course of the disease, brain involvement seems more probable in presence of extraintestinal manifestations, but this question has not yet been addressed. The present study examined the relationship between Crohn's disease and brain structure and focused on the connection with extraintestinal manifestations and markers of brain development. In a pilot study, brains of 15 patients with Crohn's disease (of which 9 had a history of extraintestinal manifestations, i.e. arthritis, erythema nodosum and primary sclerosing cholangitis) were compared to matched healthy controls using high resolution magnetic resonance imaging. Patients and controls were tested for depression, fatigue and global cognitive function. Cortical thickness, surface area and folding were determined via cortical surface modeling. The overall group comparison (i.e. all patients vs. controls) yielded no significant results. In the patient subgroup with extraintestinal manifestations, changes in cortical area and folding, but not thickness, were identified: Patients showed elevated cortical surface area in the left middle frontal lobe (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0163202