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HIV-Infected or -Exposed Children Exhibit Lower Immunogenicity to Hepatitis B Vaccine in Yaoundé, Cameroon: An Appeal for Revised Policies in Tropical Settings?

Since 2005, anti-hepatitis B virus (anti-HBV) vaccine is part of the Expanded Program on Immunization (EPI) for infants born in Cameroon, with 99% anti-HBV coverage. In a context of generalized HIV epidemiology, we assessed paediatric anti-HBV vaccine response according to HIV status, feeding option...

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Published in:PloS one 2016-09, Vol.11 (9), p.e0161714-e0161714
Main Authors: Njom Nlend, Anne Esther, Nguwoh, Philippe Salomon, Ngounouh, Christian Taheu, Tchidjou, Hyppolite Kuekou, Pieme, Constant Anatole, Otélé, Jean Mbede, Penlap, Véronique, Colizzi, Vittorio, Moyou, Roger Somo, Fokam, Joseph
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Language:English
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Summary:Since 2005, anti-hepatitis B virus (anti-HBV) vaccine is part of the Expanded Program on Immunization (EPI) for infants born in Cameroon, with 99% anti-HBV coverage. In a context of generalized HIV epidemiology, we assessed paediatric anti-HBV vaccine response according to HIV status, feeding option and age in a tropical context. Prospective, observational and cross-sectional study conducted among 82 children (27 [IQR: 9-47] months, min-max: 6-59), after complete anti-HBV vaccination (Zilbrix Hepta: 10μg AgHBs) at the Essos Health Centre in Yaounde, Cameroon, classified as group-A: HIV unexposed (28), group-B: HIV-exposed/uninfected (29), group-C: HIV-infected (25). Quantitative anti-HBs ELISA was interpreted as "no", "low-" or "protective-response" with
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0161714