Elevated Platelet to Lymphocyte Ratio Is Associated with Poor Survival Outcomes in Patients with Colorectal Cancer

Platelet to lymphocyte ratio (PLR) is a parameter reflecting inflammatory responses in patients with cancer. Several studies have investigated the prognostic value of PLR in patients with colorectal cancer (CRC); however, the results are controversial. Thus, we carried out a meta-analysis to evaluat...

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Bibliographic Details
Published in:PloS one 2016-09, Vol.11 (9), p.e0163523-e0163523
Main Authors: Gu, Xiaobin, Gao, Xian-Shu, Qin, Shangbin, Li, Xiaoying, Qi, Xin, Ma, Mingwei, Yu, Hao, Sun, Shaoqian, Zhou, Dong, Wang, Wen, Xiong, Wei
Format: Article
Language:English
Subjects:
Analysis
Angiogenesis
Bioindicators
Biology and Life Sciences
Biomarkers
Blood platelets
Cancer
Cancer metastasis
Cancer patients
Cancer therapies
Care and treatment
Cell survival
Chemotherapy
Clinical outcomes
Colorectal cancer
Colorectal carcinoma
Confidence intervals
Development and progression
Growth factors
Hospitals
Inflammation
Lung cancer
Lymphocytes
Mathematical models
Medical prognosis
Medical research
Medicine and Health Sciences
Meta-analysis
Metastases
Metastasis
Neutrophils
Oncology
Patient outcomes
Patients
Physical Sciences
Platelets
Prognosis
Radiation therapy
Rectum
Research and Analysis Methods
Studies
Subgroups
Survival
Survival analysis
Systematic review
Thrombosis
Tumors
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Summary:Platelet to lymphocyte ratio (PLR) is a parameter reflecting inflammatory responses in patients with cancer. Several studies have investigated the prognostic value of PLR in patients with colorectal cancer (CRC); however, the results are controversial. Thus, we carried out a meta-analysis to evaluate the association between PLR and CRC prognostication. Relevant articles were retrieved through PubMed, Embase, and Web of Science, and pooled hazard ratio (HR) and 95% confidence interval (CI) were computed by using STATA V.12.0. Both the random-effects model and fixed-effects model were utilized. A total of 13 studies (14 cohorts) with 8,601 patients were included in the meta-analysis. Pooled HRs and 95% CIs demonstrated that increased PLR predicted poor overall survival (OS) (HR = 1.81, 95%CI:1.42-2.31, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0163523