Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis

• Published in: PloS one 2016-10, Vol.11 (10), p.e0165117-e0165117
• Main Authors: Cheng, Ke-Yan, Wang, Zhi-Lian, Gu, Qian-Yun, Hao, Min
• Format: Article
• Language: English
• Subjects: Analysis; Apoptosis; Biology and Life Sciences; Breast cancer; Cancer metastasis; Cancer therapies; Carcinoma; Cell cycle; Cell division; Cervical cancer; Cervical carcinoma; Confidence intervals; Female; Gene Expression Regulation, Neoplastic; Gynecology; Humans; Inhibitor of Apoptosis Proteins - genetics; Inhibitor of Apoptosis Proteins - metabolism; Lymph nodes; Lymphatic system; Medical research; Medicine and Health Sciences; Meta-analysis; Metastases; Metastasis; Neoplasm Metastasis; Obstetrics; Online databases; Patients; Physical Sciences; Prognosis; Research and Analysis Methods; Squamous cell carcinoma; Studies; Survival; Survival Analysis; Survivin; Therapeutic applications; Thyroid cancer; Tumors; Up-Regulation; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0165117

Overexpression of survivin has been reported in many human tumors. However, the clinicopathological features associated with survivin overexpression in cervical carcinoma remain controversial. Thus, the current meta-analysis was performed to assess the clinicopathological significance of survivin in cervical carcinoma. PubMed, EMBASE, and Web of Science databases were searched for relevant studies published through November 1, 2015. A meta-analysis was performed to evaluate the association between survivin expression and clinicopathological outcome in cervical carcinoma. Eleven eligible studies with a total of 865 patients were included. Survivin overexpression was closely related to lymph node metastasis (odds ratio [OR] = 0.679, 95% confidence interval [CI]: 0.509-0.905, P = 0.008) but was not significantly associated with tumor FIGO stage (I+II vs. III+IV) (OR = 0.843, 95% CI: 0.626-1.137, P = 0.264), tumor grade (G1+G2 vs. G3) (OR = 0.913, 95% CI: 0.689-1.210, P = 0.527), tumor size (>4 vs. ≤4 cm) (OR = 0.825, 95% CI: 0.434-1.570, P = 0.559), or stromal involvement (OR = 0.820, 95% CI: 0.545-1.233, P = 0.340). The correlation between survivin expression and overall survival was evaluated among a total of 238 patients from three eligible studies. The pooled HR was 1.129 (95% CI: 0.597-1.661; P = 0.000), indicating that survivin expression was significantly associated with poor survival in cervical carcinoma. Based on the current meta-analysis, survivin is strongly associated with lymph node metastasis and poor prognosis. Additionally, survivin is a novel clinicopathological marker of cervical carcinoma and thus may be a therapeutic target for cervical carcinoma.