Quinoline Alkaloids Isolated from Choisya Aztec-Pearl and Their Contribution to the Overall Antinociceptive Activity of This Plant

Choisya 'Aztec-Pearl', a hybrid of Choisya ternata and Choisya dumosa var. arizonica, had the antinociceptive activity in the ethanol extract (EECA) of its leaves evaluated. Two quinoline alkaloids, anhydroevoxine (A) and choisyine (C), isolated from these leaves were also tested. The resu...

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Bibliographic Details
Published in:PloS one 2016-10, Vol.11 (10), p.e0164998
Main Authors: de Carvalho, Patricia Ribeiro, Ropero, Denise Ricoy, Pinheiro, Mariana Martins, Fernandes, Patricia Dias, Boylan, Fabio
Format: Article
Language:English
Subjects:
Acute toxicity
Alkaloids
Alkaloids - adverse effects
Alkaloids - isolation & purification
Alkaloids - pharmacology
Analgesics - adverse effects
Analgesics - pharmacology
Analysis
Anesthesiology
Animals
Biology and Life Sciences
Choisya
Choisya dumosa
Choisya dumosa arizonica
Choisya ternata
Cholinergic transmission
Chromatography
Ethanol
Herbal medicine
Kinases
Leaves
Male
Medicine and Health Sciences
Mice
Morphine
Narcotics
Nervous system
Nitric oxide
Nitrogen compounds
Pain
Pain perception
Pharmaceutical sciences
Pharmacology
Pharmacy
Physical Sciences
Plant Extracts - adverse effects
Plant Extracts - pharmacology
Quinoline
Quinolines - adverse effects
Quinolines - isolation & purification
Quinolines - pharmacology
Rutaceae - chemistry
Toxicity
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Summary:Choisya 'Aztec-Pearl', a hybrid of Choisya ternata and Choisya dumosa var. arizonica, had the antinociceptive activity in the ethanol extract (EECA) of its leaves evaluated. Two quinoline alkaloids, anhydroevoxine (A) and choisyine (C), isolated from these leaves were also tested. The results obtained pointed out to a very high antinociceptive activity measured by the hot plate model for EECA (at doses of 10, 30 and 100 mg/kg) as well as for A and C (at doses of 1, 3 and 10 mg/kg). The magnitude of the activity was two-fold higher than the one observed for the morphine treated animals for the higher doses of extracts/compounds (30, 100 mg/kg and 3, 10 mg/kg respectively). The mechanism of action for this activity was also investigated and it seems that for EECA as well as A and C, the opiate system plays an important role. Results have also shown that the nitric oxide (NO) system also play a pivotal role in the case of EECA and A while for C it seems that the cholinergic system have some involvement. The acute toxicity was evaluated for EECA with results showing no important toxic effect.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0164998