Identification of Blood Let-7e-5p as a Biomarker for Ischemic Stroke

Circulating microRNAs (miRNAs) are emerging as novel disease biomarkers. Using a miRNA microarray, we previously showed that the whole blood level of let-7e-5p was significantly higher in ischemic stroke patients than in control subjects. However, the association between let-7e-5p expression and the...

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Bibliographic Details
Published in:PloS one 2016-10, Vol.11 (10), p.e0163951
Main Authors: Huang, Suli, Lv, Ziquan, Guo, Yi, Li, Lu, Zhang, Yanwei, Zhou, Li, Yang, Binyao, Wu, Shuang, Zhang, Ying, Xie, Changhui, Li, Shanshan, Cheng, Jinquan
Format: Article
Language:English
Subjects:
Aged
Apoptosis
Atherosclerosis
Bioinformatics
Biology and life sciences
Biomarkers
Biomarkers - blood
Blood
Blood circulation
Brain Ischemia - genetics
Cardiovascular disease
Coronary vessels
Diabetes
Disease control
Disease prevention
Family medical history
Female
Gene expression
Genes
Hospitals
Humans
Hypertension
Ischemia
Laboratories
Male
MAP kinase
Medicine and Health Sciences
MicroRNA
MicroRNAs
MicroRNAs - blood
Middle Aged
miRNA
Patients
Plasma
Public health
Reclassification
Risk analysis
Risk factors
ROC Curve
Rodents
Signal transduction
Signaling
Stroke
Stroke - genetics
Transfection
U937 Cells
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Summary:Circulating microRNAs (miRNAs) are emerging as novel disease biomarkers. Using a miRNA microarray, we previously showed that the whole blood level of let-7e-5p was significantly higher in ischemic stroke patients than in control subjects. However, the association between let-7e-5p expression and the occurrence of ischemic stroke remains unknown. In this study, we validated the expression levels of let-7e-5p in two case-control populations using miRNA TaqMan assays and further investigated the potential targets of let-7e-5p. The results suggest that the blood level of let-7e-5p was significantly higher in patients with ischemic stroke than in controls (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0163951